Table 2.

Top-ranked ingredients associated with false positives on the amphetamines and buprenorphine screens.a

Screening assayIngredientOdds ratio95% CIExposure frequencyPrevious status
LowerUpper
AmphetaminesCeftaroline73.837.4150.44.8·10−4Unknown
Ceftaroline fosamil52.523.4119.03.4·10−4Unknown
Procainamide69.521.0251.21.5·10−4Unknown
Imatinib17.010.027.71.1·10−3Unknown
Methyldopa15.29.224.41.3·10−3Unknown
Esmolol10.76.117.81.3·10−3Unknown
Mexiletine10.95.619.59.8·10−4Cross-reactant
Trazodone6.05.26.84.6·10−2Cross-reactant
Dextroamphetamine5.23.67.35.6·10−3Assay target
Amphetamine5.03.57.05.6·10−3Assay target
BuprenorphineMethoxsalen34.513.987.92.8·10−4Unknown
Hydroxychloroquine14.111.217.55.7·10−3Cross-reactant
Propafenone15.18.127.27.2·10−4Unknown
Rotigotine21.37.359.12.2·10−4Unknown
Levofloxacin8.07.19.12.9·10−2Cross-reactant
Cytarabine9.26.912.33.9·10−3Unknown
Decitabine11.86.620.39.0·10−4Unknown
Belimumab15.56.037.03.1·10−4Unknown
Posaconazole9.55.216.69.3·10−4Unknown
Sulfamethoxazole6.05.26.92.5·10−2Unknown
  • a Ingredients are sorted by lower bound of the 95% CI of the odds ratio (ORFP). All tested associations for all screening assays are in Table 2 of the online Data Supplement.