Table 1.

Demographic and clinical characteristics of CKD patients in the discovery, confirmation, and replication cohorts.a

CKDnAge (years)Sex (%Fb)Race (%W)Proteinuria (g/g Cr)eGFR (mL/min/1.73 m2)SCr (mg/dL)
Discovery cohort
    HE1034.5 ± 15.350.050.0NANANA
    DN1060.4 ± 13.550.040.05.5 (0.8–11.5)34.5 (29.0–65.0)2.6 ± 1.7
    HTNb1058.5 ± 14.240.080.00.6 (0.2–3.1)32.0 (29.0–49.0)2.3 ± 1.6
    LN1038.4 ± 9.6100.030.03.0 (0.8–3.3)97.5 (77.0–123.0)0.7 ± 0.2
Confirmation stage: Boston Kidney Biopsy cohort (BKBx)
    HE11936.6 ± 13.547.557.5NANANA
    DN5859.4 ± 14.048.348.34.7 (2.0–7.2)32.0 (22.3–45.0)2.4 ± 1.4
    LN8938.8 ± 13.085.432.62.1 (1.2–3.3)90.9 (57.4–116.6)1.2 ± 1.0
Replication stage: UW diabetic nephropathy cohort
    HE3054.4 ± 13.666.283.10.009 (0.003–0.008)NANA
    DN7454.7 ± 13.033.870.30.42 (0.12–1.29)35.5 (21.0–51.0)2.5 ± 2.3
    DM7154.5 ± 12.543.776.10.006 (0.004–0.01)93.4 (79.0–106.0)0.8 ± 0.2
Replication stage: OSU lupus nephritis cohort
    HE3043.4 ± 13.163.333.3NANANA
    LN8634.3 ± 10.280.246.52.0 (1.2–3.2)79.1 (44.0–96.3)1.3 ± 0.9
    SLE3741.7 ± 13.740.562.9NA98.0 (86.0–109.0)1.0 ± 0.8
  • a Age and SCr are presented as mean ± SD. Proteinuria and eGFR are presented as median (IQR range).

  • b F, female; W, white; HTN, renovascular kidney disease.