Table 2.

Median (25th, 75th percentiles) of AGE-CML, sRAGE, esRAGE, fasting glucose, and Hb A1c in persons with diagnosed diabetes by duration of diabetes.a

Diagnosed diabetesb durationP valuec
<5 years (n = 128)5–10 years (n = 104)≥10 years (n = 222)
Fasting glucose, mg/dl, mmol/L98.00 (91.00, 106.00), 5.44 (5.05, 5.88)105.00 (96.00, 114.00), 5.83 (5.33, 6.33)113.00 (103.00, 135.00), 6.27 (5.72, 7.49)<0.001
Hb A1c, %5.40 (5.20, 5.50)5.90 (5.70, 6.00)6.70 (6.60, 7.20)<0.001
AGE-CML, ng/mL37.72 (32.19, 43.90)36.57 (31.73, 42.32)36.15 (32.25, 40.66)0.10
sRAGE, pg/mL1313.86 (1011.77, 1723.04)1204.24 (889.51, 1637.48)944.43 (773.43, 1582.90)0.33
esRAGE, ng/mL0.57 (0.43, 0.74)0.52 (0.40, 0.72)0.44 (0.33, 0.65)0.41
  • a Analyses are weighted, 9 individuals with missing diagnosed diabetes duration data (n = 454).

  • b Diagnosed diabetes was defined as self-reported diagnosis of diabetes or taking diabetes medication.

  • c P value for difference in median biomarker levels by diabetes status. Wilcoxon rank sum test was used to compare medians from 2 groups in diagnosed diabetes, K-sample equality of median test was used to compare 3 medians among no diagnosed diabetes.