Table 3. Median (range) blood pharmacokinetic group comparison in 14 frequent and 11 occasional smokers following smoking of a 6.8% cannabis cigarette.a
Analyte and parameterFrequent smokerOccasional smokerMann–Whitney UzP
THC
    Positive participants, %100100
    Cmax, μg/L34.4 (16.5–49.5)12.1 (4.1–40.3)26.0−2.636<0.01
    Postdose Cmax, μg/L34.4 (16.5–49.5)12.1 (4.1–40.3)26.0−2.636<0.01
    Postdose tmax, h0.5 (0.5–0.6)0.5 (0.5–0.6)63.5−0.4710.655
    tlast, h>30 (24.0–>30)4.0 (1.0–6.0)0−4.304<0.001
    AUC0–30104 (51.2–236.1)18.2 (3.1–57.3)0−4.215<0.001
    AUC>baseline45.2 (25.4–60.2)18.2 (3.1–57.3)30.0−2.573<0.01
11-OH-THC
    Positive participants, %100100
    Cmax, μg/L6.7 (2.2–13.4)2.9 (1.6–7.9)20.0−2.984<0.01
    Postdose Cmax, μg/L6.2 (2.2–13.4)2.9 (1.6–7.9)22.0−2.868<0.01
    Postdose tmax, h0.5 (0.5–0.6)0.5 (0.5–1.0)63.5−0.4700.656
    tlast, h12.0 (3.1–>30)3.0 (1.0–5.0)9.0−3.728<0.001
    AUC0–3032.5 (5.3–65.8)7.1 (1.7–16.7)14.0−3.280<0.001
    AUC>baseline19.5 (5.3–41.6)6.1 (0.6–16.7)22.0−3.011<0.01
THCCOOH
    Positive participants, %100100
    Cmax, μg/L52.8 (31.9–119)10.4 (6.5–27.4)0−4.142<0.001
    Postdose Cmax, μg/L48.7 (31.9–119)10.4 (6.5–27.4)0−4.142<0.001
    Postdose tmax, h0.5 (0.5–21.0)0.5 (0.5–1.0)68.5−0.1750.875
    tlast, h>30>30N/AN/AN/A
    AUC0–30689.2 (473–2591)113.4 (63.0–216)0−4.215<0.001
    AUC>baseline54.7 (12.3–212)86.9 (43.7–182)42.0−1.9160.058
CBD
    Positive participants, %15.40
    Postdose Cmax, μg/L0 (0–1.5)060.5−1.3290.482
    Postdose tmax, h0 (0–0.5)060.5−1.3290.482
    tlast, h0 (0–0.5)060.5−1.3290.482
CBN
    Positive participants, %84.636.4
    Postdose Cmax, μg/L2.2 (0–3.1)0 (0–2.8)38.0−1.994<0.05
    Postdose tmax, h0.5 (0–0.6)0 (0–0.6)41.0−1.8240.070
    tlast, h0.6 (0–2.1)0 (0–1.1)38.0−1.997<0.05
THC-glucuronide
    Positive participants, %15.49.1
    Postdose Cmax, μg/L0 (0–1.1)0 (0–0.6)66.0−0.5540.717
    Postdose tmax, h0 (0–0.5)0 (0–0.6)68.0−0.3531.000
    tlast, h0 (0–0.5)0 (0–0.6)68.0−0.3531.000
THCCOO-glucuronide
    Positive participants, %10090.9
    Cmax, μg/L84.1 (52.2–218)16.2 (0–83.4)8.0−3.777<0.001
    Postdose Cmax, μg/L74.3 (40.4–218)16.2 (0 to −83.4)12.0−3.558<0.001
    Postdose tmax, h2.1 (0.5–6.0)3.0 (0–5.0)49.5−1.5080.137
    tlast, h>3027.0 (0–>30)24.0−3.026<0.01
    AUC0–301342 (597–4264)382 (150–762)3.0−3.617<0.001
    AUC>baseline70.1 (0.37–358)212 (11.2–762)38.0−1.8740.064
  • a Values in bold are statistically significant.