Table 4. Median (range) plasma pharmacokinetic group comparison in 14 frequent and 11 occasional smokers following smoking of a 6.8% THC cannabis cigarette.a
Analyte and parameterFrequent smokerOccasional smokerMann–Whitney UzP
THC
    Positive participants, %100100
    Cmax, μg/L47.7 (26.3–69.1)16.7 (5.4–83.6)32.0−2.289<0.05
    Postdose Cmax, μg/L47.7 (26.3–69.1)16.7 (5.4–83.6)32.0−2.289<0.05
    Postdose tmax, h0.5 (0.4–1.1)0.563.5−0.4700.655
    tlast, h>304.0 (1.0–10.5)0−4.320<0.001
    AUC0–30178 (109–374)29.1 (3.6–107)3.0−4.051<0.001
    AUC>baseline61.6 (38.0–118)29.1 (3.6–107)33.0−2.409<0.05
11-OH-THC
    Positive participants, %10090.9
    Cmax, μg/L10.8 (4.0–26.4)5.3 (0–15.6)25.0−2.694<0.01
    Postdose Cmax, μg/L10.5 (3.6–26.4)5.3 (0–15.6)27.0−2.578<0.01
    Postdose tmax, h0.5 (0.4–1.1)0.6 (0–1.0)48.5−1.3400.189
    tlast, h27.1 (10.5–>30)4.0 (0–8.0)0−4.074<0.001
    AUC0–3065.0 (19.8–106)11.4 (0.9–36.0)4.0−3.865<0.001
    AUC>baseline22.9 (10.2–50.5)11.4 (0.9–36.0)23.0−2.752<0.01
THCCOOH
    Positive participants, %100100
    Cmax, μg/L96.5 (54.2–207)18.6 (11.3–59.7)2.0−4.027<0.001
    Postdose Cmax, μg/L87.0 (54.2–207)18.6 (11.3–59.7)3.0−3.969<0.001
    Postdose tmax, h0.5 (0.4–1.1)0.563.5−0.4700.655
    tlast, h>30>30N/AN/AN/A
    AUC0–301231 (759–3724)203 (124–346)0−4.215<0.001
    AUC>baseline78.7 (18.5–308)140 (84.8–344)28.0−2.682<0.01
CBD
    Positive participants, %53.89.1
    Postdose Cmax, μg/L1.1 (0–1.6)0 (0–1.3)40.0−2.175<0.05
    Postdose tmax, h0.5 (0–1.1)0 (0–0.5)40.0−2.177<0.05
    tlast, h0.5 (0–1.1)0 (0–0.5)39.0−2.246<0.05
CBN
    Positive participants, %10050.0
    Postdose Cmax, μg/L2.3 (1.0–3.7)0.5 (0–5.3)30.0−2.181<0.05
    Postdose tmax, h0.5 (0.4–1.1)0.2 (0–0.5)37.0−1.7570.080
    tlast, h1.0 (0.4–3.0)0.3 (0–2.1)34.5−1.9030.058
THC-glucuronide
    Positive participants, %92.345.5
    Postdose Cmax, μg/L1.1 (0–2.7)0 (0–5.6)48.5−1.3490.185
    Postdose tmax, h0.5 (0–0.6)0 (0–0.5)52.0−1.1500.263
    tlast, h1.0 (0–4.0)0 (0–2.1)47.5−1.4100.166
THCCOO-glucuronide
    Positive participants, %100100
    Cmax, μg/L228 (97.9–462)38.4 (15.6–156)7.0−3.832<0.001
    Postdose Cmax, μg/L149 (92.5–393)38.4 (15.6–156)13.0−3.504<0.001
    Postdose tmax, h3.0 (0.5–26.0)3.0 (1.1–3.1)65.0−0.6300.544
    tlast, h>30>30 (8–>30)42.0−1.9880.078
    AUC0–302630 (1712–9134)481 (52.8–1719)1.0−4.161<0.001
    AUC>baseline274 (1.8–1294)481 (47.3–1334)55.0−1.20.244
  • a Values in bold are statistically significant.