Table 2. Overall effect of group, time, and baseline concentration on cannabinoid blood and plasma concentrations in 14 frequent and 11 occasional smokers following smoking of a 6.8% THC cannabis cigarette.a
AnalyteEffectBloodPlasma
Not accounting for baselineAccounting for baselineNot accounting for baselineAccounting for baseline
tPtPtPtP
THCGroup34.1<0.00124.8<0.00139.6<0.00134.5<0.001
Time−6.7<0.001−9.0<0.001−6.6<0.001−5.1<0.001
Baseline concentrationN/AN/A25.1<0.001N/AN/A31.2<0.001
11-OH-THCGroup11.0<0.0014.3<0.00122.5<0.00111.7<0.001
Time−9.7<0.001−10.3<0.001−10.7<0.001−11.8<0.001
Baseline concentrationN/AN/A12.4<0.001N/AN/A14.0<0.001
THCCOOHGroup21.9<0.00117.3<0.00134.6<0.00121.1<0.001
Time−7.8<0.001−13.3<0.001−10.7<0.001−14.3<0.001
Baseline concentrationN/AN/A27.3<0.001N/AN/A18.0<0.001
CBDGroup0.0020.9990.0020.9990.0030.9980.0030.998
Time−0.0010.999−0.0010.999−0.0020.998−0.0020.998
Baseline concentrationN/AN/AN/AN/A
CBNGroup0.0020.9980.0020.9980.0050.9960.0050.996
Time−0.0030.998−0.0030.998−0.0170.987−0.0170.987
Baseline concentrationN/AN/AN/AN/A
THC-glucuronideGroup0.0040.9970.0040.9970.0050.9960.0050.996
Time−0.0060.996−0.0060.9960.0300.9760.0300.976
Baseline concentrationN/AN/AN/AN/A
THCCOO-glucuronideGroup15.4<0.00113.3<0.00120.6<0.0019.9<0.001
Time−4.4<0.001−6.0<0.001−5.8<0.001−6.5<0.001
Baseline concentrationN/AN/A15.6<0.001N/AN/A8.1<0.001
  • a Values in bold are statistically significant.