Table 2. Fractional concentrations of tumor-derived DNA in plasma determined by SNV analysis.
CaseNo. of SNVs detected in tumor tissueTime pointNo. of tumor-associated SNVs sequenced from plasma (percentage of SNVs seen in tumor tissue)No. of plasma DNA sequence reads showing SNVs (p)No. of plasma DNA sequence reads showing wild-type sequence (q)Deduced fractional concentration of tumor-derived DNA by SNV analysis Embedded ImageDeduced fractional concentration of tumor-derived DNA by GAAL analysis
HCC12840Before surgery2569 (94%)11 38931 60253%52%
After surgery44 (1.5%)9146 8980.4%0.9%
HCC23105Before surgery1097 (35%)149057 8655.0%5.6%
After surgery72 (2.3%)20666 6920.6%0.9%
HCC33171Before surgery461 (15%)52548 8862.1%4.3%
After surgery31 (1%)6758 8620.2%1.4%
HCC41334Before surgery201 (15%)24818 5272.6%7.6%
After surgery74 (5.5%)14922 1441.3%2.7%