Table 2. Variations in the sensitivity and specificity (at cut-off values 500 ng/mL and 1000 ng/mL) and the ROC area of the D-dimer test according to various other test results or patient characteristics.
D-dimer >500D-dimer >1000D-dimer (continuous)
SensitivitySpecificitySensitivitySpecificityAUCa (CI)
Overall0.970.370.890.550.86 (0.84–0.88)
Previous lung embolism
    Yes (n = 173)1.000.370.840.530.82 (0.75–0.90)
    No (n = 1913)0.970.370.890.550.86 (0.84–0.88)
Malignancy
    Yes (n = 115)0.950.250.950.440.86 (0.79–0.93)
    No (n = 1971)0.970.380.890.550.84 (0.83–0.87)
Recent surgery
    Yes (n = 278)0.960.220.900.380.84 (0.78–0.90)
    No (n = 1808)0.970.390.890.570.86 (0.84–0.88)
Leg trauma
    Yes (n = 344)0.960.320.850.480.79 (0.72–0.87)
    No (n = 1742)0.970.380.890.560.86 (0.84–0.89)
Pitting edema
    Yes (n = 1301)0.970.320.880.500.84 (0.82–0.87)
    No (n = 785)0.970.460.900.620.87 (0.84–0.91)
Pregnancy
    Yes (n = 45)1.000.281.000.550.98 (0.00–1.00)
    No (n = 2041)0.970.370.890.550.85 (0.83–0.88)
  • a AUC, area under the ROC curve.