Table 2. Baseline characteristics by quartile of Lp-PLA2 in the subcohort sample reweighted to the population.a
VariablesQuartile of Lp-PLA2 activity or massP for trendb
Q1Q2Q3Q4
Lp-PLA2 activity, mmol/min/mLc128.4163.7194.4236.7
    Age, y61.262.563.663.30.0014
    Black race, %9.69.25.74.40.0002
    White race, %79.984.285.489.30.0007
    Height, cm161.9160.2162.0162.10.28
    Weight, kg70.071.772.773.40.023
    BMI, kg/m226.727.427.427.80.047
    Current smoking, %5.13.96.37.50.19
    Hormone therapy, %
        Current74.250.942.424.7<0.0001
        Past6.811.517.712.40.0017
    BP, mmHg
        SBP127.0125.8125.0127.60.81
        DBPd75.374.674.075.20.73
    Antihypertensive medication use, %24.022.720.822.30.53
    Total cholesterol, mg/dL209.8222.8232.8258.4<0.0001
    HDL, mg/dL63.958.353.650.5<0.0001
    Cholesterol-lowering medication, %6.18.78.46.70.79
    Statin use, %4.58.58.25.70.52
    hsCRP, mg/Lc3.52.42.02.0<0.0001
    Diabetes, %4.22.14.24.20.73
    Hb A1c (if diabetic), %6.67.08.57.50.030
    Angina, %1.43.02.12.50.47
    Family history of early MI, %16.419.517.425.10.040
Lp-PLA2 mass, ng/mLc329.9432.3515.8649.2
    Age, y61.362.962.763.70.0019
    Black race, %10.98.04.55.40.0003
    White race, %76.086.088.688.2<0.0001
    Height, cm161.9161.1161.4161.8>0.99
    Weight, kg72.270.572.972.30.60
    BMI, kg/m227.527.327.027.50.85
    Current smoking, %4.03.97.17.70.046
    Hormone therapy, %
        Current62.755.543.330.5<0.0001
        Past8.112.710.617.00.0029
    Blood pressure, mmHg
        SBP127.0126.0124.9127.50.95
        DBP75.274.574.375.20.87
    Antihypertensive medication use, %24.925.616.822.50.13
    Total cholesterol, mg/dL205.5224.9230.7262.6<0.0001
    HDL, mg/dL56.757.955.156.70.53
    Cholesterol-lowering medication, %9.29.15.36.30.038
    Statin use, %7.48.75.25.50.10
    hsCRP, mg/Lc3.22.81.82.1<0.0001
    Diabetes, %5.93.71.33.80.17
    Hb A1c (if diabetic), %6.97.97.87.80.19
    Angina, %1.43.31.82.50.63
    Family history of early MI, %18.119.819.321.00.48
  • a Mean or percentage except as noted.

  • b Test for trend in means using linear regression or in proportions using logistic regression.

  • c Median. Test for hsCRP is based on natural logs.

  • d DBP, diastolic BP.