Table 3. Performance of kinetic changes in hs-cTnT within the initial 6 h for rule-in and rule-out of non-STEMI in the entire study population.
Sensitivity (95% CI)Specificity (95% CI)PPV (95% CI)NPV (95% CI)NRIa
Change ≥20%75.2 (67.8–81.5)58.1 (54.1–62.0)32.4 (27.7–37.3)89.8 (86.4–92.5)
Change ≥30%63.6 (55.8–71.0)75.1 (71.5–78.5)40.5 (34.5–46.8)88.6 (85.5–91.2)0.055
Change ≥39.8%b57.6 (49.7–65.2)83.0 (79.8–85.9)47.5 (40.4–54.6)88.0 (85.1–90.5)0.072
Change ≥50%52.7 (44.8–60.5)87.5 (84.7–90.0)53.1 (45.1–60.9)87.4 (84.5–89.9)0.070
Change ≥100%35.4 (28.1–43.2)95.3 (93.3–96.8)66.7 (55.8–76.4)84.8 (81.9–87.3)−0.029
Change ≥250%23.2 (17.0–30.4)99.2 (98.1–99.7)88.4 (74.9–96.1)83.0 (80.0–85.6)−0.110
Change ≥5.0 ng/L100 (97.8–100)55.4 (51.4–59.4)37.4 (32.9–42.1)98.3 (96.3–99.4)0.185c
Change ≥9.2 ng/Lb89.7 (84.0–93.9)74.8 (71.2–78.2)48.7 (42.9–54.5)96.5 (94.4–97.9)0.311c
Change ≥20 ng/L72.7 (65.2–79.4)87.7 (84.9–90.2)61.2 (54.0–68.1)92.4 (89.9–94.4)0.272c
Change ≥50 ng/L52.1 (44.2–60.0)95.2 (93.2–96.7)74.1 (65.2–81.8)88.2 (85.5–90.5)0.140
Change ≥100 ng/L37.6 (30.2–45.4)97.4 (95.8–98.5)79.5 (68.8–87.8)85.4 (82.6–87.9)0.017
Change ≥200 ng/L28.5 (21.7–36.0)98.7 (97.5–99.4)85.5 (73.3–93.5)83.8 (80.9–86.4)−0.061
  • a Vs relative δ change ≥20%.

  • b ROC-based optimal cutoff for discrimination of non-STEMI.

  • c P < 0.001.