Table 1. Analytical characteristics of contemporary sensitive and point-of-care cardiac troponin assays.
Company/platform/assayCardiac troponin concentration at:Amino acid residues of epitopes recognized by capture (C) and detection (D) MAbs
LoD,a μg/L99th Percentile, μg/L (CV)b10% CV concentration, μg/L
Abbott AxSYM ADV0.020.04 (14%)0.16C: 87–91, 41–49; D: 24–40
Abbott ARCHITECT0.0090.028 (14%)0.032C: 87–91, 24–40; D: 41–49
Abbott i-STAT0.020.08 (16.5%)0.10C: 41–49, 88–91; D: 28–39, 62–78
Alere Triage0.05<0.05 (NA)NAC: NA; D: 27–40
Alere Triage Cardio3c0.010.02 (17%)NAC: 27–39; D: 83–93, 190–196
Beckman Access AccuTnI0.010.04 (14%)0.06C: 41–49; D: 24–40
bioMérieux Vidas Ultra0.010.01 (27.7%)0.11C: 41–49, 22–29; D: 87–91, MAb 7B9
Mitsubishi Pathfast0.0080.029 (5.0%)0.014C: 41–49; D: 71–116, 163–209
Ortho Vitros ECi ES0.0120.034 (10%)0.034C: 24–40, 41–49; D: 87–91
Radiometer AQT90 cTnI0.0090.023 (17.7%)0.039C: 41–49, 190–196; D: 137–149
Radiometer AQT90 cTnT0.0080.017 (15.2%)0.026C: 125–131; D: 136–147
Response RAMP0.03<0.01 (18.5% at 0.05)0.21C: 85–92; D: 26–38
Roche cobas h232 Cardiac Tc,d0.05NANAC: 125–131; D: 136–147
Roche Elecsys TnT Gen 40.01<0.010.030C: 136–147; D: 125–131
Roche Elecsys TnI0.160.16 (10%)0.30C: 87–91, 190–196; D: 23–29, 27–43
Roche Cardiac Reader cTnTe0.03NANAC: 125–131; D: 136–147
Siemens Centaur Ultra0.0060.04 (8.8%)0.03C: 41–49, 87–91; D: 27–40
Siemens Dimension RxL0.040.07 (20%)0.14C: 27–32; D: 41–56
Siemens Immulite 25000.10.2 (NA)0.42C: 87–91; D: 27–40
Siemens Stratus CS0.030.07 (10%)0.06C: 27–32; D: 41–56
Siemens Vista0.0150.045 (10%)0.04C: 27–32; D: 41–56
Tosoh AIA0.06<0.06 (NA)0.09C: 41–49; D: 87–91
  • a LoD, limit of detection; NA, not available; Gen 4, fourth-generation assay.

  • b CV at 99th percentile.

  • c Not cleared by the US Food and Drug Administration.

  • d Standardized against hs-cTnT assay.

  • e Standardized against Gen 4 cTnT assay.