Table 1.

Analytical performance of tests for ox-LDL, characteristics of study cohort, and clinical applicability of ox-LDL.

Ox-LDL test 1 (n = 675)Ox-LDL test 2 (n = 675)Variance
Analytical (within-person) variance, %23 (16)26 (9.7)
Between person variance, %7774
Estimated reliability of a personal mean (n = 9)0.970.96
Characteristics of patients
Non-CHD (n = 44)CHD (n = 51) P
Mean (SD) age, years57 (19)67 (12)0.002
Sex, % male4857NS1
Diseased vessels (1, 2, or 3), %33, 24, 8
Previous ACS, %33
Noncoronary forms of CVD, %55NS
Diabetes, %3020NS
Risk equivalents, %3427NS
Mean (SD) LDL-C, mg/L1110 (350)1210 (330)NS
Mean (SD) HDL-C, mg/L630 (210)540 (150)<0.05
Mean (SD) triglycerides, mg/L1050 (490)1290 (680)<0.05
Mean (SD) SBP, mmHg107 (62)102 (69)NS
Smoking, %520<0.01
Mean (SD) ox-LDL (test 1), mg/L8.0 (4.7)13.4 (8.1)<0.001
Mean (SD) ox-LDL (test 2), units/L44 (13)54 (12)<0.001
ROC analysis
CHD vs non-CHDAUC2Sensitivity, %Specificity, %
 Ox-LDL test 10.72 (0.62–0.81)6771
 Ox-LDL test 20.72 (0.61–0.80)7861
CHD vs healthy controls
 Ox-LDL test 10.85 (0.74–0.92)8080
 Ox-LDL test 20.85 (0.75–0.93)8775
Prevalence of CHD according to ox-LDL
Low ox-LDLHigh ox-LDLP for difference
Ox-LDL test 14.3 (1.4–12)3
Ox-LDL test 23.3 (1.1–10)3NS
  • 1 NS, not significant; ACS, acute coronary syndrome; CVD, cardiovascular disease; LDL-C, LDL-cholesterol; HDL-C, HDL-cholesterol; SBP, systolic blood pressure; AUC, area under the curve.

  • 2 Mean (95% confidence interval).

  • 3 Odds ratio and 95% confidence intervals in fourth quartile compared with first quartile. Cutoff value for ox-LDL 1 was 15 mg/L in test 1 and 65 units/L in test 2.