Table 1.

Human diseases that were found to be associated with increased oxidative stress on the basis of (potential) biomarkers of oxidative damage.

BiomarkerReference(s)BiomarkerReference(s)
MDA Sickle cell disease(23)(64)
 AD(11)(43) Spinal cord injury(23)(64)
 ALS(43) Systemic lupus erythematosus(23)
 Asthma(42) Systemic sclerosis (scleroderma)(23)(24)(64)
 Atherosclerosis(3)(40) Unstable angina(23)
 Cutaneous leishmaniasis(176) Zellweger syndrome(82)
 Diabetes mellitus(39)Decrease in GSH concentration and/or GSH:GSSG ratio
 Preeclampsia(41)
HNE ARDS(101)
 AD(5)(50)(51)(53) Alcoholic liver disease(90)
 Atherosclerosis(3) AD(90)
 Cardiovascular disease(57) ALS(90)
 COPD(59)(60) Asbestosis(101)
 Mild cognitive impairment(53) Asthma(101)
 PD(56) Ataxia telangiectasia(90)(93)
Acrolein Cancer(99)
 Atherosclerosis(58) Cardiovascular disease(90)(98)
 Cardiovascular disease(57) Cataract genesis(90)
 Mild cognitive impairment(53) Diabetes mellitus (both types)(5)(90)(93)
F2-IsoPs HIV-positive patients(90)(93)(101)
 ARDS(23)(24)(64) Idiopathic pulmonary fibrosis(101)
 Acute and chronic alcoholic liver disease(24) Ischemic brain(97)
 PD(96)
 Acute chest syndrome of sickle cell disease(23) Preeclampsia(93)
 Respiratory distress syndrome(90)
 AD(23)(24)(64)(68)(83) Retinopathy of prematurity(93)
 Asthma(24)(42) Rheumatoid arthritis(90)
 Atherosclerosis(23)(24)(64) Werner syndrome(90)
 Cardiopulmonary bypass(64)S-Glutathionylated proteins
 Cardiovascular disease(80) Cataract genesis(105)(177)
 Chronic kidney disease(147) Diabetes (types 1 and 2)(104)
 COPD(5)(23)(24)(79) Friedreich ataxia(90)
 Coronary artery disease(24) HIV infections(178)
 Creutzfeldt–Jakob disease(23)(24) Hyperlipidemia(104)
 Crohn disease(23)(24) Renal cell carcinoma(104)
 Cystic fibrosis(23)(24)(64)(78) Spherocytosis(5)
 Diabetes (types 1 and 2)(23)(24)(64) Uremia associated with hemodialysis or peritoneal dialysis(104)
 Down syndrome(23)(24)
 Heart failure(24)(64)
 Hepatic cirrhosis(23)NO2-Tyr
 Huntington disease(23)(24) ARDS(5)
 Hypercholesterolemia(23)(24)(64) AD(132)
 Hyperhomocysteinemia(23)(24) ALS(5)(132)
 Ischemia/Reperfusion injury(24) Asthma(5)
 Interstitial lung disease(23) Atherosclerosis(5)
 Multiple sclerosis(24) Cardiovascular disease(125)
 Myocardial infarction(23) COPD(5)
 Obesity(24) Coronary artery disease(123)(124)(125)
 Osteoarthritis(64) Crohn disease(5)
 Osteoporosis(24) Cystic fibrosis(107)(118)
 Pancreatitis(23) Diabetes (types 1 and 2)(179)(180)
 Primary biliary cirrhosis(24) Hypercholesterolemia(5)
 Psoriatic arthritis(64) Lung cancer(129)(130)(131)
 Pulmonary hypertension(23)(64) Lung injury(31)
 Reactive arthritis(23)(64) Multiple sclerosis(5)
 Rheumatoid arthritis(23)(64) Myocardial inflammation(5)