Table 3.

Potential markers for predicting response or resistance to specific cancer therapies.

MarkerMalignancyDrug(s)Ref(s).
MGMT1GliomaAlkylating agents(68)
Topoisomerase II╬▒BreastAnthracyclines(69)
uPA and PAI-1BreastChemotherapy (adjuvant)(70)(71)
uPA and PAI-1BreastHormone (advanced disease)(72)(73)
EGFRBreastHormone (advanced disease)(74)
pS2BreastHormone (early disease)(75)
VEGFBreastHormone and chemotherapy (advanced disease)(76)
VEGFBreastRadiotherapy(77)
TIMP-3BreastHormone therapy(78)
YB-1BreastChemotherapy(79)
c-kit mutationsGISTImatinib(80)
EGFR mutationsNSCL cancerGefitinib(81)(82)