Table 1.

Approximate molar abundance and masses of polypeptides in plasma from healthy subjects, based on literature survey.

RankPolypeptideConcentration μmol/LMr
1Albumin500–80066 400
2Immunoglobulin κ, light chain68–15023 000
3Immunoglobulin γ1, heavy chain40–13052 000
4Immunoglobulin λ, light chain36–8423 000
5Immunoglobulin γ2, heavy chain20–9052 000
6Apolipoprotein A-I30–7028 100
7Apolipoprotein A-II30–608700
8Transferrin25–4579 000
9α1-Antitrypsin18–4050 000
10Immunoglobulin α1, heavy chain8–5057 000
11Haptoglobin β-chain6–4035 000
12Transthyretin subunit15–3013 800
13Haptoglobin, α1-chain0–409200
14Haptoglobin, α2-chain0–4015 900
15α2HS-glycoprotein, heavy chain9–3038 400
16α2HS-glycoprotein, light chain9–304000
17Fibrinogen, α-chain10–2767 600
18Fibrinogen, β-chain10–2752 300
19Fibrinogen, γ-chain9–2449 000
20Hemopexin9–2057 000
21α1-Acid glycoprotein, gene 19–2040 000
22Immunoglobulin μ, heavy chain4–2570 000
23Apolipoprotein C-III6–209000
24α2-Macroglobulin subunit7–17180 000
25Gc-Globulin8–1451 000
26Immunoglobulin γ3, heavy chain2–1650 000
27Apolipoprotein C-I6–126631
28C3, α-chain5–10110 000
29C3, β-chain5–1075 000
30α1-Acid glycoprotein, gene 24–1040 000
31Immunoglobulin γ4, heavy chain0.3–1350 000
32α1-Antichymotrypsin4–968 000
33Apolipoprotein D2–1023 000
34β2-Glycoprotein I3–640 000
35C4b–binding protein, α-chain3–675 000
36Apolipoprotein A-IV3–643 000
37Apolipoprotein C-II2–78900
38Serum amyloid A4413 000
39Bikunin chain, inter-α-trypsin inhibitor3–530 000
40Immunoglobulin α2, heavy chain1–755 000
41Antithrombin III3–565 000
42α1B-Glycoprotein3–563 000
Continued on page 1611