Table 1.

Genotype frequencies of IL-4 −590C/T and IL-4Rα Ile50Val polymorphisms in patients with autoimmune thyroid disease and in controls.

Hashimoto diseasePGraves diseasePControls (n = 47)
Severe1 (n = 35)Mild2 (n = 39)Intractable3 (n = 50)In remission4 (n = 26)
IL-4 −590C/T
 CC7 (20.0%)0 (0.0%)4 (8.0%)2 (7.7%)3 (6.4%)
 CT13 (37.1%)17 (43.6%)0.0034522 (44.0%)11 (42.3%)NS5619 (40.4%)
 TT15 (42.9%)22 (56.4%)24 (48.0%)13 (50.0%)25 (53.2%)
 CC vs T carriage
 CC7 (20.0%)0 (0.0%)0.003774 (8.0%)2 (7.7%)NS73 (6.4%)
 CT + TT28 (80.0%)39 (100.0%)46 (92.0%)24 (92.3%)44 (93.6%)
IL-4Rα Ile50Val
 IleIle4 (11.4%)4 (10.3%)NS57 (14.0%)4 (15.4%)NS56 (12.8%)
 IleVal21 (60.0%)24 (61.5%)23 (46.0%)13 (50.0%)26 (55.3%)
 ValVal10 (28.6%)11 (28.2%)20 (40.0%)9 (34.6%)15 (31.9%)
 IleIle vs Val carriage
 IleIle4 (11.4%)3 (10.3%)NS77 (14.0%)4 (15.4%)NS76 (12.8%)
 IleVal + ValVal31 (88.6%)32 (89.7%)43 (86.0%)22 (84.6%)41 (87.2%)
Clinical characteristics at sample collection8
 Age, y52.1 (10.0)56.2 (6.6)50.2 (16.1)49.1 (14.1)47.6 (12.2)
 Female/male, n30/530/941/924/240/7
 Free T4, ng/L14.1 (3.5)11.9 (1.4)14.1 (9.8)13.3 (4.6)ND
 Free T3, ng/L2.43 (0.54)2.90 (0.31)3.14 (2.81)2.96 (1.49)ND
 TSH, mU/L3.18 (1.13)2.21 (1.72)2.79 (0.77)1.97 (1.32)ND
 TRAb, IU/L<1.0<1.05.63 (11.36)<1.0ND
 McAb, 2n × 1005.9 (2.7)2.0 (2.4)4.6 (2.6)5.6 (2.1)Negative
 TgAb, 2n × 1007.7 (3.1)1.7 (2.7)2.7 (2.8)1.6 (1.5)Negative
 Goiter size, cm3.7 (1.7)4.9 (1.5)4.5 (1.0)4.2 (0.5)Impalpable
 TreatmentL-thyroxineNoneThiamazole or PTUNoneNone
  • 1 Hashimoto disease patients <50 years old who developed hypothyroidism and were treated with L-thyroxine.

  • 2 Untreated and euthyroid Hashimoto disease patients >50 years old.

  • 3 Graves disease patients who remained positive for TRAb despite being treated by antithyroid drug for more than 5 years.

  • 4 Graves disease patients in remission who have been euthyroid and negative for TRAb for more than 2 years after cessation of anti-thyroid drug treatment.

  • 5 Analyzed by χ2 test.

  • 6 NS, not significant; ND, not determined; T4, thyroxine; T3, triiodothyronine; TSH, thyrotropin; TRAb, antithyrotropin receptor antibody; McAb, antithyroid microsomal antibody; TgAb, antithyroglobulin antibody; PTU, Propylthiouracil.

  • 7 Analyzed by Fisher exact test.

  • 8 Results of clinical characteristics are expressed as mean (SD).