Table 4.

Incidence density and adjusted RR for incident diabetes and hypertension from year 10 to year 15 by serum GGT at year 10 in the CARDIA Study, 1995–2001.

OutcomeGGT at year 10P for trend
<25%25% to <50%50% to <75%75% to <90%≥90%
Incident cases of diabetes
 Cases/person-years1/37898/503415/473919/269714/1610
 Incidence density, per 1000 person-years0.31.63.27.08.7
 Adjusted RR
  Model 111.06.0 (0.8–48.5)10.4 (1.4–80.4)24.4 (3.2–187.2)28.3 (3.6–223.4)<0.001
  Model 221.06.0 (0.7–48.5)10.7 (1.4–82.0)26.1 (3.4–199.3)34.3 (4.3–270.02)<0.001
  Model 331.04.5 (0.6–36.2)6.3 (0.8–48.8)11.0 (1.4–85.4)15.5 (1.9–122.9)<0.001
  Model 441.03.5 (0.4–28.9)5.1 (0.7–39.6)7.0 (0.9–55.4)8.7 (1.1–71.3)0.010
Incident cases of hypertension
 Cases/person-years21/367572/467277/420268/234838/1268
 Incidence density, per 1000 person-years5.715.418.329.030.0
 Adjusted RR
  Model 111.02.5 (1.5–4.1)2.5 (1.5–4.0)3.8 (2.3–6.4)3.4 (1.9–6.0)<0.001
  Model 221.02.5 (1.5–4.1)2.5 (1.5–4.0)3.9 (2.3–6.4)3.5 (2.0–6.1)<0.001
  Model 331.02.4 (1.5–4.0)2.2 (1.3–3.6)3.1 (1.8–5.3)2.8 (1.6–5.1)<0.001
  Model 441.02.3 (1.4–3.9)2.0 (1.2–3.3)2.8 (1.6–4.8)2.1 (1.1–3.8)0.034