Table 1.

Reported cases of abnormal Hb associated with high and low HbA1c.

Abnormal HbAmino acid abnormalityAge, ySexDiagnosisFBG, mg/LHbA1c observed, %
High HbA1c
Pavieα135(H18)Val→Glu45MDM125
Cape Townα92Arg→Gln61MDM116022.3
Sherwood Forestα2β2104(G6)Arg→Thr88FNIDDM51.8
Okayamaα2β22(NA2)His→Gln880
Andrew-Minneapolisβ144(HC1)Lys→Asp34FPregnancy toxycosis37.4
Turriffα99(G6)Lys→Glu29FDM22
Hafniaα2(β116(G18)His→Gln)26MDM50
Mitoβ144(HC1)Lys→Glu63FHypertension36
Long IslandβN-Val→Met31MDM51
NiigataβN-Methionyl-1(NA)Val→Leu58M98013.1Present case
Low HbA1c
Takamatsuβ120Lys→Gln70MNIDDM16203.6
Himejiβ140Ala→Asp31F10802
52MNIDDM18605.1
Camdenβ131Gln→Glu75FDM34307.6
34MDM3790
Riyadhβ120Lys→Asn52FDM12003.1
55MNIDDM13603.5
74MNIDDM21903
Hamadanβ56(D7)Gly→Arg7FIDDM16104.3
K-Woolwichβ132Lys→Gln70F6.1
  • 1 DM, diabetes mellitus; NIDDM, non-insulin-dependent diabetes mellitus.