Table 4.

Selected toxicokinetic parameters for analgesics monitoring.a

AnalgesicsToxic doseToxic concentration
Salicylate (acetylsalicylic acid)140 mg/kg (acute ingestion)>300 mg/L1
Diflunisal7.5 gm (adults)800–1000 mg/L
Acetaminophen140 mg/kg (acute ingestion)150 mg/L2
(RS)-(+/−)-Ibuprofen>3 g or 100 mg/kg200–500 mg/L
(S)-(+)-NaproxenVariable200–400 mg/L