Proposed assay criteria for analgesics monitoring.
Analgesics | Method | Samples1 | Qualitative | Quantitative | TAT2 | Sensitivity | Precision, CV |
---|---|---|---|---|---|---|---|
Salicylate | Trinders | S/P/U | X | <1 h | |||
(Acetylsalicylic acid) | Colorimetric | S/P/U | X | <1 h | 28 mg/L | ||
Immunoassays | S/P/U | X | <1 h | 50 mg/L | 5–10% | ||
HPLC, GC | All | X | 1–4 h | ||||
Diflunisal | Trinders | S/P/U | X | <1 h | |||
TLC3 | S/P/U | X | <1 h | ||||
HPLC, GC | All | X | 1–2 h | 50 mg/L | 5–10% | ||
Acetaminophen | TLC | U | X | <1 h | |||
HPLC | All | X | 1 h | 10 mg/L | 5–10% | ||
FPIA | All | X | <1 h | 10 mg/L | 5–10% | ||
(RS)-(+/−)-Ibuprofen | HPLC, GC | All | X | 1–2 h | 15 mg/L | 5–10% | |
Chiral HPLC | All | X | |||||
(S)-(+)-Naproxen | TLC | U | X | <1 h | |||
HPLC, GC | All | X | 1–2 h | 50 mg/L | 5–10% | ||
Chiral HPLC | All | X | |||||
(+/−)-Tramadol | TLC | U | X | <1 h | |||
HPLC, GC | All | X | 1–2 h | 25 μg/L4 | 20%4 | ||
HPLC (REMEDi) | U | X | <1 h | ||||
GC–MS | All | X | X | 1–2 h |