Table 2.

Proposed assay criteria for analgesics monitoring.

Analgesics	Method	Samples¹	Qualitative	Quantitative	TAT²	Sensitivity	Precision, CV
Salicylate	Trinders	S/P/U	X		<1 h
(Acetylsalicylic acid)	Colorimetric	S/P/U		X	<1 h	28 mg/L
	Immunoassays	S/P/U		X	<1 h	50 mg/L	5–10%
	HPLC, GC	All		X	1–4 h
Diflunisal	Trinders	S/P/U	X		<1 h
	TLC³	S/P/U	X		<1 h
	HPLC, GC	All		X	1–2 h	50 mg/L	5–10%
Acetaminophen	TLC	U	X		<1 h
	HPLC	All		X	1 h	10 mg/L	5–10%
	FPIA	All		X	<1 h	10 mg/L	5–10%
(RS)-(+/−)-Ibuprofen	HPLC, GC	All		X	1–2 h	15 mg/L	5–10%
	Chiral HPLC	All		X
(S)-(+)-Naproxen	TLC	U	X		<1 h
	HPLC, GC	All		X	1–2 h	50 mg/L	5–10%
	Chiral HPLC	All		X
(+/−)-Tramadol	TLC	U	X		<1 h
	HPLC, GC	All		X	1–2 h	25 μg/L⁴	20%⁴
	HPLC (REMEDi)	U	X		<1 h
	GC–MS	All	X	X	1–2 h