Table 2.

Proposed assay criteria for analgesics monitoring.

AnalgesicsMethodSamples1QualitativeQuantitativeTAT2SensitivityPrecision, CV
SalicylateTrindersS/P/UX<1 h
(Acetylsalicylic acid)ColorimetricS/P/UX<1 h28 mg/L
ImmunoassaysS/P/UX<1 h50 mg/L5–10%
HPLC, GCAllX1–4 h
DiflunisalTrindersS/P/UX<1 h
TLC3S/P/UX<1 h
HPLC, GCAllX1–2 h50 mg/L5–10%
AcetaminophenTLCUX<1 h
HPLCAllX1 h10 mg/L5–10%
FPIAAllX<1 h10 mg/L5–10%
(RS)-(+/−)-IbuprofenHPLC, GCAllX1–2 h15 mg/L5–10%
Chiral HPLCAllX
(S)-(+)-NaproxenTLCUX<1 h
HPLC, GCAllX1–2 h50 mg/L5–10%
Chiral HPLCAllX
(+/−)-TramadolTLCUX<1 h
HPLC, GCAllX1–2 h25 μg/L420%4
HPLC (REMEDi)UX<1 h
GC–MSAllXX1–2 h