Table 3.

Analgesic medications metabolized by cytochrome P450.

Medication classFamilyMedication classFamily
Acetaminophen1A2, 2E1
NSAIDsOpioids
Diclofenac2C9 (probe)Codeine2D6
Ibuprofen2C9Methadone3A4, 2D6
Mefenamic acid2C9Fentanyl3A4
Naproxen2C9, 1A2Tramadol2D6
Piroxicam2C9Hydrocodone2D6
Lornoxicam2C9Oxycodone2D6
Aceclofenac2C9Sufentanyl3A4
Flurbiprofen2C9Dihydrocodeine2D6
Enoxicam2C9Alfentanil3A4
Pirprofen2C9