Table 2.

Diagnostic sensitivity and specificity of presentation hs-cTnT and cTnT for AMI at the different cutoffs studied, with and without incorporation of initial ECG findings.

Assay and cutoffSensitivity (95% CI)Specificity (95% CI)PPV (95% CI)NPV (95% CI)
cTnT
    0.01 μg/La70.9 (59.6–80.6)92.7 (89.6–95.1)66.7 (55.5–76.6)93.9 (91.0–96.1)
hs-cTnT
    14 ng/La94.9 (87.5–98.6)72.4 (67.6–76.8)41.4 (34.2–49.0)98.6 (96.4–99.6)
    5 ng/Lb98.7 (93.2–100.0)24.7 (20.5–29.4)21.3 (17.2–25.8)99.0 (94.3–100.0)
    3 ng/Lc100.0 (95.4–100.0)6.3 (4.1–9.2)18.0 (14.5–21.9)100.0 (85.8–100.0)
    14 ng/L and no ECG ischemiad98.7 (93.2–100.0)61.2 (56.1–66.1)34.4 (28.2–40.9)99.6 (97.7–100.0)
    <5 ng/L and no ECG ischemiad100.0 (95.4–100.0)20.8 (16.9–25.2)20.6 (16.7–25.0)100.0 (95.5–100.0)
    <3 ng/L and no ECG ischemiad100.0 (95.4–100.0)5.7 (3.6–8.6)17.9 (14.5–21.8)100.0 (83.9–100.0)
  • a Cutoff set at the 99th percentile of a reference population.

  • b Cutoff set at the limit of detection of the assay.

  • c Cutoff set at the limit of blank of the assay.

  • d AMI ruled out only if both conditions met.