Table 3.

Diagnostic sensitivity and specificity of presentation hs-cTnT and cTnT for MACE within 30 days at the different cutoffs studied, with and without incorporation of initial ECG findings.

Assay and cutoffSensitivity (95% CI)Specificity (95% CI)PPV (95% CI)NPV (95% CI)
cTnT
    0.01 μg/La62.2 (51.9–71.8)93.7 (90.7–96.0)72.6 (61.8–81.8)90.2 (86.8–93.0)
hs-cTnT
    14 ng/La89.8 (82.0–95.0)74.5 (69.7–78.9)48.6 (41.1–56.2)96.5 (93.6–98.3)
    5 ng/Lb99.0 (94.5–100.0)26.0 (21.6–30.9)26.4 (22.0–31.3)99.0 (94.3–100.0)
    3 ng/Lc100.0 (96.3–100.0)3.6 (2.3–5.3)13.3 (10.9–15.9)100.0 (85.8–100.0)
    14 ng/L and no ECG ischemiad94.9 (88.5–98.3)63.3 (58.1–68.2)41.0 (34.5–47.7)97.9 (95.1–99.3)
    <5 ng/L and no ECG ischemiad100.0 (96.3–100.0)21.9 (17.8–26.5)25.6 (21.3–30.3)100.0 (95.5–100.0)
    <3 ng/L and no ECG ischemiad100.0 (96.3–100.0)6.0 (3.8–9.0)22.2 (18.4–26.4)100.0 (84.6–100.0)
  • a Cutoff set at the 99th percentile of a reference population.

  • b Cutoff set at the limit of detection of the assay.

  • c Cutoff set at the limit of blank of the assay.

  • d AMI ruled out only if both conditions met.