Table 1.

CSF biomarker concentrations for protocol 1 (fractionated sampling) and 2 (centrifugation).

BiomarkerMedian (range)Protocol 1: C3 and C7.1 (fractions)Protocol 2: C7.1 and C7.1* (centrifugation)
C3 (n = 20)C7.1 (n = 20)C7.1* (n = 20)Median difference, % (95% CI)PaMedian difference, % (95% CI)Pa
Aβ1–42, pg/mL421 (269–855)421 (223–907)426 (246–875)−1.10 (−5.46 to 3.47)0.6152.29 (−2.30 to 7.10)0.315
T-tau, pg/mL411 (71–2183)368 (63–1224)386 (63–1466)4.32 (−4.91 to 14.45)0.3510.91 (−5.01 to 7.19)0.758
0.53 (−7.33 to 9.06)0.892
P-tau181P, pg/mL61 (13–239)59 (13–299)58 (13–318)−0.18 (−3.94 to 3.72)0.921−0.03 (−3.63 to 3.71)0.988
  • a None of the comparisons were statistically significant.