Table 1.

Baseline characteristics across increasing sex-specific quartiles of cTnI.

CharacteristicQuartile 1Quartile 2Quartile 3Quartile 4PaP for trendb
nValuenValuenValuenValue
cTnI range, ng/L
    Men10870.0–2.610872.7–3.711203.8–5.611375.7–610.8
    Women12750.0–1.912642.0–2.714072.8–4.113354.2–363.1
Mean age, years (SD)236039.2 (12.6)235144.7 (14.0)252752.0 (14.6)247263.2 (15.3)<0.001<0.001
Clinical characteristics
    Diabetes mellitus, n (%)236026 (1.1)234931 (1.3)252273 (2.9)2459146 (5.9)<0.001<0.001
    Hypertension, n (%)235750 (2.1)2344117 (5.0)2522273 (10.8)2463631 (25.6)<0.001<0.001
    Myocardial infarction, n (%)235612 (0.5)234816 (0.7)251946 (1.8)2455208 (8.5)<0.001<0.001
    Current smoker, n (%)2345807 (34.4)2330689 (29.6)2500746 (29.8)2434492 (20.2)<0.0010.013
    Mean systolic blood pressure, mmHg (SD)2353126.1 (15.4)2341131.1 (17.6)2571137.8 (20.1)2459150.3 (24.9)<0.001<0.001
Laboratory measurements
    Mean eGFR, mL · min−1 · (1.73 m2)−1 (SD)236077.4 (12.0)235174.3 (12.1)252770.9 (12.2)247265.2 (14.4)<0.001<0.001
    Mean cholesterol, mg/dL (SD)c2360197 (40)2351219 (41)2527239 (44)2472249 (50)<0.001<0.001
    Mean HDL cholesterol, mg/dL (SD)236056 (15)235154 (15)252453 (15)247253 (16)<0.001<0.001
    Geometric mean CRP, mg/L (95% CI)23600.61 (0.57–0.66)23500.81 (0.75–0.86)25250.96 (0.91–1.02)24691.32 (1.24–1.40)<0.001<0.001
  • a χ2 test was used for categorical variables, ANOVA for continuous variables.

  • b Cochran–Armitage test was used for categorical variables. For continuous variables, each case was assigned a median inside of each quartile, and the correlation was calculated between the new variable and the category number.

  • c To convert cholesterol concentrations from mg/dL to mmol/L, multiply by 0.02586.