RT Journal Article SR Electronic T1 Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge JF Clinical Chemistry JO Clin. Chem. FD American Association for Clinical Chemistry SP 499 OP 502 VO 18 IS 6 A1 Friedewald, William T. A1 Levy, Robert I. A1 Fredrickson, Donald S. YR 1972 UL http://clinchem.aaccjnls.org/content/18/6/499.abstract AB A method for estimating the cholesterol content of the serum low-density lipoprotein fraction (Sf0-20) is presented. The method involves measurements of fasting plasma total cholesterol, triglyceride, and high-density lipoprotein cholesterol concentrations, none of which requires the use of the preparative ultracentrifuge. Comparison of this suggested procedure with the more direct procedure, in which the ultracentrifuge is used, yielded correlation coefficients of .94 to .99, depending on the patient population compared.