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Research ArticleArticle

Direct Estimation of HDL-Mediated Cholesterol Efflux Capacity from Serum

Sanna Kuusisto, Michael V. Holmes, Pauli Ohukainen, Antti J. Kangas, Mari Karsikas, Mika Tiainen, Markus Perola, Veikko Salomaa, Johannes Kettunen, Mika Ala-Korpela
DOI: 10.1373/clinchem.2018.299222 Published July 2019
Sanna Kuusisto
Computational Medicine, Faculty of Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland; NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland;
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Michael V. Holmes
Medical Research Council Population Health Research Unit, University of Oxford, Oxford, UK; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK; National Institute for Health Research, Oxford Biomedical Research Centre, Oxford University Hospital, Oxford, UK; Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK;
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Pauli Ohukainen
Computational Medicine, Faculty of Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland;
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Antti J. Kangas
Nightingale Health Ltd., Helsinki, Finland;
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Mari Karsikas
Computational Medicine, Faculty of Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland;
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Mika Tiainen
Nightingale Health Ltd., Helsinki, Finland;
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Markus Perola
Department of Health, National Institute for Health and Welfare, Helsinki, Finland; Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland; Estonian Genome Center, University of Tartu, Tartu, Estonia;
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Veikko Salomaa
Department of Health, National Institute for Health and Welfare, Helsinki, Finland;
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Johannes Kettunen
Computational Medicine, Faculty of Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland; Department of Health, National Institute for Health and Welfare, Helsinki, Finland;
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Mika Ala-Korpela
Computational Medicine, Faculty of Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland; NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland; Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK; Population Health Science, Bristol Medical School, University of Bristol, Bristol, UK; Systems Epidemiology, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia; Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Faculty of Medicine, Nursing and Health Sciences, The Alfred Hospital, Monash University, Melbourne, VIC, Australia.
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  • For correspondence: mika.ala-korpela@baker.edu.au
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Article Information

vol. 65 no. 8 1042-1050
DOI 
https://doi.org/10.1373/clinchem.2018.299222
PubMed 
30996052

Published By 
Clinical Chemistry
Print ISSN 
0009-9147
Online ISSN 
1530-8561
History 
  • Received for publication November 2, 2018
  • Accepted for publication March 14, 2019
  • Published online July 29, 2019.

Article Versions

  • Latest version (April 17, 2019 - 09:51).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2019 American Association for Clinical Chemistry

Author Information

  1. Sanna Kuusisto1,2,
  2. Michael V. Holmes3,4,5,6,
  3. Pauli Ohukainen1,
  4. Antti J. Kangas7,
  5. Mari Karsikas1,
  6. Mika Tiainen7,
  7. Markus Perola8,9,10,
  8. Veikko Salomaa8,
  9. Johannes Kettunen1,8 and
  10. Mika Ala-Korpela1,2,6,11,12,13,*
  1. 1 Computational Medicine, Faculty of Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland;
  2. 2 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland;
  3. 3 Medical Research Council Population Health Research Unit, University of Oxford, Oxford, UK;
  4. 4 Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK;
  5. 5 National Institute for Health Research, Oxford Biomedical Research Centre, Oxford University Hospital, Oxford, UK;
  6. 6 Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK;
  7. 7 Nightingale Health Ltd., Helsinki, Finland;
  8. 8 Department of Health, National Institute for Health and Welfare, Helsinki, Finland;
  9. 9 Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland;
  10. 10 Estonian Genome Center, University of Tartu, Tartu, Estonia;
  11. 11 Population Health Science, Bristol Medical School, University of Bristol, Bristol, UK;
  12. 12 Systems Epidemiology, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia;
  13. 13 Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Faculty of Medicine, Nursing and Health Sciences, The Alfred Hospital, Monash University, Melbourne, VIC, Australia.
  1. ↵* Address correspondence to this author at: Baker Heart and Diabetes Institute, 75 Commercial Rd., Melbourne, Victoria 3004, Australia. E-mail mika.ala-korpela{at}baker.edu.au.
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Clinical Chemistry: 65 (8)
Vol. 65, Issue 8
August 2019
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Direct Estimation of HDL-Mediated Cholesterol Efflux Capacity from Serum
Sanna Kuusisto, Michael V. Holmes, Pauli Ohukainen, Antti J. Kangas, Mari Karsikas, Mika Tiainen, Markus Perola, Veikko Salomaa, Johannes Kettunen, Mika Ala-Korpela
Clinical Chemistry Aug 2019, 65 (8) 1042-1050; DOI: 10.1373/clinchem.2018.299222
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Direct Estimation of HDL-Mediated Cholesterol Efflux Capacity from Serum
Sanna Kuusisto, Michael V. Holmes, Pauli Ohukainen, Antti J. Kangas, Mari Karsikas, Mika Tiainen, Markus Perola, Veikko Salomaa, Johannes Kettunen, Mika Ala-Korpela
Clinical Chemistry Aug 2019, 65 (8) 1042-1050; DOI: 10.1373/clinchem.2018.299222

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