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DiscussionQ&A

The Role of Procalcitonin in Diagnosis of Sepsis and Antibiotic Stewardship: Opportunities and Challenges

Angela W.S. Fung, Daniel Beriault, Eleftherios P. Diamandis, Carey-Ann D. Burnham, Todd Dorman, Mark Downing, Joshua Hayden, Bradley J. Langford
DOI: 10.1373/clinchem.2017.272294 Published August 2017
Angela W.S. Fung
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada;
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Daniel Beriault
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Department of Laboratory Medicine, St. Michael's Hospital, Toronto, ON, Canada;
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Eleftherios P. Diamandis
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada; Department of Clinical Biochemistry, University Health Network, Toronto, ON, Canada;
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  • For correspondence: Eleftherios.Diamandis@sinaihealthsystem.ca
Carey-Ann D. Burnham
Medical Director of Clinical Microbiology, Associate Professor of Pediatrics, Associate Professor of Molecular Microbiology, Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO;
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Todd Dorman
Senior Associate Dean for Education Coordination, Associate Dean Continuing Medical Education, Professor and Vice Chair for Critical Care, Department of Anesthesiology & Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD;
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Mark Downing
Head of Infectious Disease and Medical Director of Antimicrobial Stewardship Program, St. Joseph's Health Centre, Toronto, ON, Canada;
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Joshua Hayden
Assistant Director of Central Laboratory, Director of Toxicology and Therapeutic Drug Monitoring, and Assistant Professor, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY;
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Bradley J. Langford
Lead Pharmacist, Antimicrobial Stewardship, St. Joseph's Health Centre, Toronto, ON, Canada; Pharmacist Consultant, Antimicrobial Stewardship, Public Health Ontario, Toronto, ON, Canada.
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Article Information

vol. 63 no. 9 1436-1441
DOI 
https://doi.org/10.1373/clinchem.2017.272294
PubMed 
28634222

Published By 
Clinical Chemistry
Print ISSN 
0009-9147
Online ISSN 
1530-8561
History 
  • Received for publication April 6, 2017
  • Accepted for publication April 25, 2017
  • Published online August 28, 2017.

Article Versions

  • Latest version (June 20, 2017 - 09:44).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2017 American Association for Clinical Chemistry

Author Information

  1. Angela W.S. Fung, Moderator1,
  2. Daniel Beriault, Moderator1,2,
  3. Eleftherios P. Diamandis, Moderator1,3,4,*,
  4. Carey-Ann D. Burnham, Expert5,
  5. Todd Dorman, Expert6,
  6. Mark Downing, Expert7,
  7. Joshua Hayden, Expert8 and
  8. Bradley J. Langford, Expert9,10
  1. 1 Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada;
  2. 2 Department of Laboratory Medicine, St. Michael's Hospital, Toronto, ON, Canada;
  3. 3 Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada;
  4. 4 Department of Clinical Biochemistry, University Health Network, Toronto, ON, Canada;
  5. 5 Medical Director of Clinical Microbiology, Associate Professor of Pediatrics, Associate Professor of Molecular Microbiology, Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO;
  6. 6 Senior Associate Dean for Education Coordination, Associate Dean Continuing Medical Education, Professor and Vice Chair for Critical Care, Department of Anesthesiology & Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD;
  7. 7 Head of Infectious Disease and Medical Director of Antimicrobial Stewardship Program, St. Joseph's Health Centre, Toronto, ON, Canada;
  8. 8 Assistant Director of Central Laboratory, Director of Toxicology and Therapeutic Drug Monitoring, and Assistant Professor, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY;
  9. 9 Lead Pharmacist, Antimicrobial Stewardship, St. Joseph's Health Centre, Toronto, ON, Canada;
  10. 10 Pharmacist Consultant, Antimicrobial Stewardship, Public Health Ontario, Toronto, ON, Canada.
  1. ↵* Address correspondence to this author at: Mount Sinai Hospital, 60 Murray St., 6th Fl., Toronto, ON M5G 1X5, Canada. Fax 416-586-8628; e-mail Eleftherios.Diamandis{at}sinaihealthsystem.ca
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Clinical Chemistry: 63 (9)
Vol. 63, Issue 9
September 2017
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The Role of Procalcitonin in Diagnosis of Sepsis and Antibiotic Stewardship: Opportunities and Challenges
Angela W.S. Fung, Daniel Beriault, Eleftherios P. Diamandis, Carey-Ann D. Burnham, Todd Dorman, Mark Downing, Joshua Hayden, Bradley J. Langford
Clinical Chemistry Sep 2017, 63 (9) 1436-1441; DOI: 10.1373/clinchem.2017.272294
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The Role of Procalcitonin in Diagnosis of Sepsis and Antibiotic Stewardship: Opportunities and Challenges
Angela W.S. Fung, Daniel Beriault, Eleftherios P. Diamandis, Carey-Ann D. Burnham, Todd Dorman, Mark Downing, Joshua Hayden, Bradley J. Langford
Clinical Chemistry Sep 2017, 63 (9) 1436-1441; DOI: 10.1373/clinchem.2017.272294

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