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Clinical Chemistry

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Table of Contents

January 2017; volume 63, issue 1

Preamble

  • You have access
    Cardiovascular Disease: Impact of Biomarkers, Proteomics, and Genomics
    Fred S. Apple, Louise Cullen, G. Michael Felker, Geoffrey Ginsburg, David Morrow
    Clinical Chemistry Jan 2017, 63 (1) 1-4; DOI: 10.1373/clinchem.2016.263350

Interview

  • You have access
    An Interview with Robert Califf
    Misia Landau
    Clinical Chemistry Jan 2017, 63 (1) 5-13; DOI: 10.1373/clinchem.2016.254623

Reflection

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    Apolipoprotein E: Remarkable Protein Sheds Light on Cardiovascular and Neurological Diseases
    Robert W. Mahley
    Clinical Chemistry Jan 2017, 63 (1) 14-20; DOI: 10.1373/clinchem.2016.255695

Editorials

  • You have access
    One Shot to Rule Out: Does the Limit of Detection of a High-Sensitivity Troponin Assay Hit the Mark?
    Richard Body, Charles Reynard
    Clinical Chemistry Jan 2017, 63 (1) 21-23; DOI: 10.1373/clinchem.2016.266460
  • You have access
    Reconciling Systems for Acute Myocardial Infarction Definition and Coding Classification
    L. Kristin Newby
    Clinical Chemistry Jan 2017, 63 (1) 24-26; DOI: 10.1373/clinchem.2016.266999
  • You have access
    The Role of Emerging Biomarkers in Unraveling the Complex Biology Underlying Associations between HDL Cholesterol and Cardiovascular Diseases
    Aeron M. Small, Nehal N. Mehta, Daniel J. Rader
    Clinical Chemistry Jan 2017, 63 (1) 27-29; DOI: 10.1373/clinchem.2016.267922
  • You have access
    Troponin Autoantibodies: From Assay Interferent to Mediator of Cardiotoxicity
    Jason Y. Park, Allan S. Jaffe
    Clinical Chemistry Jan 2017, 63 (1) 30-32; DOI: 10.1373/clinchem.2016.268920

Perspective

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    Demystifying HDL Cholesterol—A “Human Knockout” to the Rescue?
    Amit V. Khera, Paul M Ridker
    Clinical Chemistry Jan 2017, 63 (1) 33-36; DOI: 10.1373/clinchem.2016.258244

Q&A

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    Best Practices for Monitoring Cardiac Troponin in Detecting Myocardial Injury
    Fred S. Apple, Allan S. Jaffe, Scott Sharkey, Peter Kavsak, Michael C. Kontos, Amy K. Saenger, Stephen Smith
    Clinical Chemistry Jan 2017, 63 (1) 37-44; DOI: 10.1373/clinchem.2016.257428

Clinical Case Study

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    A 61-Year-Old Woman with Muscle Fatigue and Increased Cardiac Troponin
    William A. Parsonage, Jane E. Mikli, Janelle C. Nisbet, Christian Hamilton-Craig, George A. Marshall
    Clinical Chemistry Jan 2017, 63 (1) 45-47; DOI: 10.1373/clinchem.2016.254631
  • You have access
    Commentary
    W.W.M. Pim Pijnappel, Pieter A. van Doorn, Ans T. van der Ploeg
    Clinical Chemistry Jan 2017, 63 (1) 48; DOI: 10.1373/clinchem.2016.265280
  • You have access
    Commentary
    Allan S. Jaffe
    Clinical Chemistry Jan 2017, 63 (1) 48-49; DOI: 10.1373/clinchem.2016.265298

Mini-Reviews

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    Natriuretic Peptides and Analytical Barriers
    Vlad C. Vasile, Allan S. Jaffe
    Clinical Chemistry Jan 2017, 63 (1) 50-58; DOI: 10.1373/clinchem.2016.254714
  • You have access
    Interpreting Cardiac Biomarkers in the Setting of Chronic Kidney Disease
    Christopher R. deFilippi, Charles A. Herzog
    Clinical Chemistry Jan 2017, 63 (1) 59-65; DOI: 10.1373/clinchem.2016.254748
    Podcast
  • You have access
    Evolving Use of Natriuretic Peptides as Part of Strategies for Heart Failure Prevention
    Ken McDonald, Mark Wilkinson
    Clinical Chemistry Jan 2017, 63 (1) 66-72; DOI: 10.1373/clinchem.2016.255075
  • You have access
    Cardiac Troponin Assays: Guide to Understanding Analytical Characteristics and Their Impact on Clinical Care
    Fred S. Apple, Yader Sandoval, Allan S. Jaffe, Jordi Ordonez-Llanos
    Clinical Chemistry Jan 2017, 63 (1) 73-81; DOI: 10.1373/clinchem.2016.255109
  • You have access
    Consensus or Controversy?: Evolution of Criteria for Myocardial Infarction After Percutaneous Coronary Intervention
    Pierluigi Tricoci
    Clinical Chemistry Jan 2017, 63 (1) 82-90; DOI: 10.1373/clinchem.2016.255208
  • You have access
    Biomarkers for Clinical Decision-Making in the Management of Pulmonary Embolism
    Evangelos Giannitsis, Hugo A. Katus
    Clinical Chemistry Jan 2017, 63 (1) 91-100; DOI: 10.1373/clinchem.2016.255240
    Podcast
  • You have access
    Myocardial Infarction Type 2 and Myocardial Injury
    Yader Sandoval, Kristian Thygesen
    Clinical Chemistry Jan 2017, 63 (1) 101-107; DOI: 10.1373/clinchem.2016.255521
    Podcast
  • You have access
    Biochemistry, Therapeutics, and Biomarker Implications of Neprilysin in Cardiorenal Disease
    Yang Chen, John C. Burnett
    Clinical Chemistry Jan 2017, 63 (1) 108-115; DOI: 10.1373/clinchem.2016.262907

Reviews

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    Issues and Challenges in Diagnostic Sequencing for Inherited Cardiac Conditions
    Roddy Walsh, Stuart A. Cook
    Clinical Chemistry Jan 2017, 63 (1) 116-128; DOI: 10.1373/clinchem.2016.254698
  • You have access
    Early Rule-Out and Rule-In Strategies for Myocardial Infarction
    Louise A. Cullen, Nicholas L. Mills, Simon Mahler, Richard Body
    Clinical Chemistry Jan 2017, 63 (1) 129-139; DOI: 10.1373/clinchem.2016.254730
    Podcast
  • You have access
    Growth Differentiation Factor 15 as a Biomarker in Cardiovascular Disease
    Kai C. Wollert, Tibor Kempf, Lars Wallentin
    Clinical Chemistry Jan 2017, 63 (1) 140-151; DOI: 10.1373/clinchem.2016.255174
  • You have access
    Application of Biomarkers for Risk Stratification in Patients with Atrial Fibrillation
    Ziad Hijazi, Jonas Oldgren, Agneta Siegbahn, Lars Wallentin
    Clinical Chemistry Jan 2017, 63 (1) 152-164; DOI: 10.1373/clinchem.2016.255182
  • You have access
    State of the Art: Blood Biomarkers for Risk Stratification in Patients with Stable Ischemic Heart Disease
    Torbjørn Omland, Harvey D. White
    Clinical Chemistry Jan 2017, 63 (1) 165-176; DOI: 10.1373/clinchem.2016.255190
  • You have access
    Use of Pharmacogenetic Information in the Treatment of Cardiovascular Disease
    Kevin Friede, Josephine Li, Deepak Voora
    Clinical Chemistry Jan 2017, 63 (1) 177-185; DOI: 10.1373/clinchem.2016.255232
  • You have access
    Use of Biomarkers in Predicting the Onset, Monitoring the Progression, and Risk Stratification for Patients with Type 2 Diabetes Mellitus
    Benjamin M. Scirica
    Clinical Chemistry Jan 2017, 63 (1) 186-195; DOI: 10.1373/clinchem.2016.255539
  • You have access
    The Changing Face of HDL and the Best Way to Measure It
    Sotirios K. Karathanasis, Lita A. Freeman, Scott M. Gordon, Alan T. Remaley
    Clinical Chemistry Jan 2017, 63 (1) 196-210; DOI: 10.1373/clinchem.2016.257725
  • You have access
    Beyond Natriuretic Peptides for Diagnosis and Management of Heart Failure
    Nasrien E. Ibrahim, James L. Januzzi
    Clinical Chemistry Jan 2017, 63 (1) 211-222; DOI: 10.1373/clinchem.2016.259564
  • You have access
    Application of Cardiac Troponin in Cardiovascular Diseases Other Than Acute Coronary Syndrome
    Kai M. Eggers, Bertil Lindahl
    Clinical Chemistry Jan 2017, 63 (1) 223-235; DOI: 10.1373/clinchem.2016.261495
  • You have access
    Biomarkers and Genetics in Peripheral Artery Disease
    Surovi Hazarika, Brian H. Annex
    Clinical Chemistry Jan 2017, 63 (1) 236-244; DOI: 10.1373/clinchem.2016.263798

Opinions

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    A Roadmap to Successful Clinical Proteomics
    Ian Wright, Jennifer E. Van Eyk
    Clinical Chemistry Jan 2017, 63 (1) 245-247; DOI: 10.1373/clinchem.2016.254664
  • You have access
    Biomarkers for Cardiovascular Screening: Progress or Passé?
    Brendan M. Everett, Paul M Ridker
    Clinical Chemistry Jan 2017, 63 (1) 248-251; DOI: 10.1373/clinchem.2016.254854
  • You have access
    Where Are the Stroke Markers?
    W. Frank Peacock
    Clinical Chemistry Jan 2017, 63 (1) 252-254; DOI: 10.1373/clinchem.2016.255091
  • You have access
    Genomics-Inspired Biomarkers and Diagnostics—Where Are They?
    Geoffrey S. Ginsburg
    Clinical Chemistry Jan 2017, 63 (1) 255-257; DOI: 10.1373/clinchem.2016.266114
  • You have access
    Payer Perspectives on Coverage of Biomarker Testing in Cardiovascular Disease
    Sean R. Tunis, Donna A. Messner
    Clinical Chemistry Jan 2017, 63 (1) 258-260; DOI: 10.1373/clinchem.2016.268136

Point/Counterpoint

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    Point: The Use of Sex-Specific Cutpoints for High-Sensitivity Cardiac Troponin Assays
    Louise A. Cullen, Nicholas L. Mills
    Clinical Chemistry Jan 2017, 63 (1) 261-263; DOI: 10.1373/clinchem.2016.254672
  • You have access
    Counterpoint: Potential Concerns Regarding the Use of Sex-Specific Cutpoints for High-Sensitivity Troponin Assays
    Evangelos Giannitsis
    Clinical Chemistry Jan 2017, 63 (1) 264-266; DOI: 10.1373/clinchem.2016.254680

Articles

  • Lipids, Lipoproteins, and Cardiovascular Risk Factors

    • You have access
      A Novel Lipid Biomarker Panel for the Detection of Heart Failure with Reduced Ejection Fraction
      Matthias Mueller-Hennessen, Hans-Dirk Düngen, Matthias Lutz, Tobias Daniel Trippel, Michael Kreuter, Johanna Sigl, Oliver J. Müller, Elvis Tahirovic, Henning Witt, Philipp Ternes, Susan Carvalho, Erik Peter, Dietrich Rein, Philipp Schatz, Felix Herth, Evangelos Giannitsis, Tanja Weis, Norbert Frey, Hugo A. Katus
      Clinical Chemistry Jan 2017, 63 (1) 267-277; DOI: 10.1373/clinchem.2016.257279
    • You have access
      Plasma N-terminal Prosomatostatin and Risk of Incident Cardiovascular Disease and All-Cause Mortality in a Prospective Observational Cohort: the PREVEND Study
      Ali Abbasi, Lyanne M. Kieneker, Eva Corpeleijn, Ron T. Gansevoort, Rijk O.B. Gans, Joachim Struck, Rudolf A. de Boer, Hans L. Hillege, Ronald P. Stolk, Gerjan Navis, Stephan J.L. Bakker
      Clinical Chemistry Jan 2017, 63 (1) 278-287; DOI: 10.1373/clinchem.2016.259275
    • You have access
      A Novel Protein Glycan–Derived Inflammation Biomarker Independently Predicts Cardiovascular Disease and Modifies the Association of HDL Subclasses with Mortality
      Robert W. McGarrah, Jacob P. Kelly, Damian M. Craig, Carol Haynes, Ryan C. Jessee, Kim M. Huffman, William E. Kraus, Svati H. Shah
      Clinical Chemistry Jan 2017, 63 (1) 288-296; DOI: 10.1373/clinchem.2016.261636
    • You have access
      Increased Trimethylamine N-Oxide Portends High Mortality Risk Independent of Glycemic Control in Patients with Type 2 Diabetes Mellitus
      W. H. Wilson Tang, Zeneng Wang, Xinmin S. Li, Yiying Fan, Daniel S. Li, Yuping Wu, Stanley L. Hazen
      Clinical Chemistry Jan 2017, 63 (1) 297-306; DOI: 10.1373/clinchem.2016.263640
    • You have access
      High-Sensitivity Troponin I in Stable Patients with Atherosclerotic Disease in the TRA 2°P - TIMI 50 Trial
      Alon Eisen, Marc P. Bonaca, Petr Jarolim, Benjamin M. Scirica, Harvey D. White, Michal Tendera, Mikael Dellborg, Jose C. Nicolau, Joao Morais, Keith A.A. Fox, Erin A. Bohula, Sabina A. Murphy, Eugene Braunwald, David A. Morrow
      Clinical Chemistry Jan 2017, 63 (1) 307-315; DOI: 10.1373/clinchem.2016.264788
  • Proteomics and Protein Markers

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      C-Type Natriuretic Peptides in Coronary Disease
      Timothy C.R. Prickett, Robert N. Doughty, Richard W. Troughton, Chris M. Frampton, Gillian A. Whalley, Chris J. Ellis, Eric A. Espiner, A. Mark Richards
      Clinical Chemistry Jan 2017, 63 (1) 316-324; DOI: 10.1373/clinchem.2016.257816
    • You have access
      Growth Differentiation Factor 15 Predicts All-Cause Morbidity and Mortality in Stable Coronary Heart Disease
      Emil Hagström, Claes Held, Ralph A.H. Stewart, Philip E. Aylward, Andrzej Budaj, Christopher P. Cannon, Wolfgang Koenig, Sue Krug-Gourley, Emile R. Mohler, Philippe Gabriel Steg, Elizabeth Tarka, Ollie Östlund, Harvey D. White, Agneta Siegbahn, Lars Wallentin
      Clinical Chemistry Jan 2017, 63 (1) 325-333; DOI: 10.1373/clinchem.2016.260570
    • You have access
      Association of Repeatedly Measured High-Sensitivity–Assayed Troponin I with Cardiovascular Disease Events in a General Population from the MORGAM/BiomarCaRE Study
      Maria F. Hughes, Francisco Ojeda, Olli Saarela, Torben Jørgensen, Tanja Zeller, Tarja Palosaari, Mark G. O'Doherty, Anders Borglykke, Kari Kuulasmaa, Stefan Blankenberg, Frank Kee
      Clinical Chemistry Jan 2017, 63 (1) 334-342; DOI: 10.1373/clinchem.2016.261172
    • You have access
      Anti–Cardiac Troponin Autoantibodies Are Specific to the Conformational Epitopes Formed by Cardiac Troponin I and Troponin T in the Ternary Troponin Complex
      Alexandra V. Vylegzhanina, Alexander E. Kogan, Ivan A. Katrukha, Olga V. Antipova, Andrey N. Kara, Anastasia V. Bereznikova, Ekaterina V. Koshkina, Alexey G. Katrukha
      Clinical Chemistry Jan 2017, 63 (1) 343-350; DOI: 10.1373/clinchem.2016.261602
    • You have access
      Specificity of B-Type Natriuretic Peptide Assays: Cross-Reactivity with Different BNP, NT-proBNP, and proBNP Peptides
      Amy K. Saenger, Olaia Rodriguez-Fraga, Ranka Ler, Jordi Ordonez-Llanos, Allan S. Jaffe, Jens Peter Goetze, Fred S. Apple
      Clinical Chemistry Jan 2017, 63 (1) 351-358; DOI: 10.1373/clinchem.2016.263749
    • You have access
      Unraveling the Molecular Complexity of O-Glycosylated Endogenous (N-Terminal) pro–B-Type Natriuretic Peptide Forms in Blood Plasma of Patients with Severe Heart Failure
      Bernhard Halfinger, Angelika Hammerer-Lercher, Benno Amplatz, Bettina Sarg, Leopold Kremser, Herbert H. Lindner
      Clinical Chemistry Jan 2017, 63 (1) 359-368; DOI: 10.1373/clinchem.2016.265397
    • You have access
      Rapid Rule-Out of Acute Myocardial Injury Using a Single High-Sensitivity Cardiac Troponin I Measurement
      Yader Sandoval, Stephen W. Smith, Anoop S.V. Shah, Atul Anand, Andrew R. Chapman, Sara A. Love, Karen Schulz, Jing Cao, Nicholas L. Mills, Fred S. Apple
      Clinical Chemistry Jan 2017, 63 (1) 369-376; DOI: 10.1373/clinchem.2016.264523
    • You have access
      Glial Fibrillary Acidic Protein Serum Levels Distinguish between Intracerebral Hemorrhage and Cerebral Ischemia in the Early Phase of Stroke
      Sebastian Luger, Jens Witsch, Andreas Dietz, Gerhard F. Hamann, Jens Minnerup, Hauke Schneider, Matthias Sitzer, Katja E. Wartenberg, Marion Niessner, Christian Foerch
      Clinical Chemistry Jan 2017, 63 (1) 377-385; DOI: 10.1373/clinchem.2016.263335
    • You have access
      Soluble CD146 Is a Novel Marker of Systemic Congestion in Heart Failure Patients: An Experimental Mechanistic and Transcardiac Clinical Study
      Mattia Arrigo, Quynh A. Truong, Duygu Onat, Jackie Szymonifka, Etienne Gayat, Heli Tolppanen, Malha Sadoune, Ryan T. Demmer, Ka Y. Wong, Jean Marie Launay, Jane-Lise Samuel, Alain Cohen-Solal, James L. Januzzi, Jagmeet P. Singh, Paolo C. Colombo, Alexandre Mebazaa
      Clinical Chemistry Jan 2017, 63 (1) 386-393; DOI: 10.1373/clinchem.2016.260471
    • You have access
      Immediate Rule-Out of Acute Myocardial Infarction Using Electrocardiogram and Baseline High-Sensitivity Troponin I
      Johannes Tobias Neumann, Nils Arne Sörensen, Francisco Ojeda, Tjark Schwemer, Jonas Lehmacher, Saskia Gönner, Nikolas Jarsetz, Till Keller, Sarina Schaefer, Thomas Renné, Ulf Landmesser, Peter Clemmensen, Nataliya Makarova, Renate B. Schnabel, Tanja Zeller, Mahir Karakas, John W. Pickering, Martin Than, William Parsonage, Jaimi Greenslade, Louise Cullen, Dirk Westermann, Stefan Blankenberg
      Clinical Chemistry Jan 2017, 63 (1) 394-402; DOI: 10.1373/clinchem.2016.262659
      Podcast
  • Evidence-Based Medicine and Test Utilization

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      Rule-In and Rule-Out of Myocardial Infarction Using Cardiac Troponin and Glycemic Biomarkers in Patients with Symptoms Suggestive of Acute Coronary Syndrome
      Colleen Shortt, Jinhui Ma, Natasha Clayton, Jonathan Sherbino, Richard Whitlock, Guillaume Pare, Stephen A. Hill, Matthew McQueen, Shamir R. Mehta, P.J. Devereaux, Andrew Worster, Peter A. Kavsak
      Clinical Chemistry Jan 2017, 63 (1) 403-414; DOI: 10.1373/clinchem.2016.261545
  • Other Areas of Clinical Chemistry

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      Discordance between ICD-Coded Myocardial Infarction and Diagnosis according to the Universal Definition of Myocardial Infarction
      Jorge Díaz-Garzón, Yader Sandoval, Stephen W. Smith, Sara Love, Karen Schulz, Sarah E. Thordsen, Benjamin K. Johnson, Brian Driver, Katherine Jacoby, Michelle D. Carlson, Kenneth W. Dodd, Johanna Moore, Nathaniel L. Scott, Charles A. Bruen, Ryan Hatch, Fred S. Apple
      Clinical Chemistry Jan 2017, 63 (1) 415-419; DOI: 10.1373/clinchem.2016.263764
    • You have access
      Trimethylamine N-oxide and Risk Stratification after Acute Myocardial Infarction
      Toru Suzuki, Liam M. Heaney, Donald J. L. Jones, Leong L. Ng
      Clinical Chemistry Jan 2017, 63 (1) 420-428; DOI: 10.1373/clinchem.2016.264853
      Podcast

Citation Classic

  • You have access
    Redefining the Gold Standard of Myocardial Infarction Using Troponin T
    E. Magnus Ohman
    Clinical Chemistry Jan 2017, 63 (1) 429-430; DOI: 10.1373/clinchem.2016.267047

Letter to the Editor

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    Low Concentrations of High-Sensitivity Troponin T at Presentation to the Emergency Department
    Edward Carlton, Jason Kendall, Ahmed Khattab, Kim Greaves
    Clinical Chemistry Jan 2017, 63 (1) 431-432; DOI: 10.1373/clinchem.2016.262139

Clinical Chemist

  • Genetic Metabolic Series

    • You have access
      Dilated Cardiomyopathy in a 2-Year-Old Infant
      Roy W.A. Peake, Kevin P. Daly
      Clinical Chemistry Jan 2017, 63 (1) 433-435; DOI: 10.1373/clinchem.2016.268508
  • What Is Your Guess?

    • You have access
      Increased Cardiac Troponin T and N-Terminal B-Type Natriuretic Peptide in a 78-Year-Old Woman Admitted for Dizziness
      Johannes M. Mair
      Clinical Chemistry Jan 2017, 63 (1) 435-436; DOI: 10.1373/clinchem.2016.265603
    • You have access
      The Rise and Fall of Cardiac Troponin T
      Richard Body, Garry McDowell
      Clinical Chemistry Jan 2017, 63 (1) 437; DOI: 10.1373/clinchem.2016.265629
    • You have access
      Gastroesophageal Reflux?
      Kenneth W. Dodd, Stephen W. Smith
      Clinical Chemistry Jan 2017, 63 (1) 438-439; DOI: 10.1373/clinchem.2016.265637
    • You have access
      Does This Patient Have Acute Myocardial Infarction?
      Geza S. Bodor
      Clinical Chemistry Jan 2017, 63 (1) 439-440; DOI: 10.1373/clinchem.2016.265751
  • Unveiling the Right Side

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      Winter and Spring in the Myocardium
      Usha Anand
      Clinical Chemistry Jan 2017, 63 (1) 441-442; DOI: 10.1373/clinchem.2016.265736
  • Science in the Arts

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      Physical Exercise: the Virtual Movement Culture?
      Marek H. Dominiczak
      Clinical Chemistry Jan 2017, 63 (1) 443-444; DOI: 10.1373/clinchem.2016.266759
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In this issue

Clinical Chemistry: 63 (1)
Vol. 63, Issue 1
January 2017
  • Table of Contents
  • About the Cover
  • Index by author
  • Table of Contents (PDF)
  • Cover (PDF)
  • Advertising (PDF)
  • Ed Board (PDF)
  • Front Matter (PDF)
  • Audio summary of this issue

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  • Preamble
  • Interview
  • Reflection
  • Editorials
  • Perspective
  • Q&A
  • Clinical Case Study
  • Mini-Reviews
  • Reviews
  • Opinions
  • Point/Counterpoint
  • Articles
    • Lipids, Lipoproteins, and Cardiovascular Risk Factors
    • Proteomics and Protein Markers
    • Evidence-Based Medicine and Test Utilization
    • Other Areas of Clinical Chemistry
  • Citation Classic
  • Letter to the Editor
  • Clinical Chemist
    • Genetic Metabolic Series
    • What Is Your Guess?
    • Unveiling the Right Side
    • Science in the Arts

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