Table of Contents

Articles

• Lipids, Lipoproteins, and Cardiovascular Risk Factors

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    A Novel Lipid Biomarker Panel for the Detection of Heart Failure with Reduced Ejection Fraction

    Matthias Mueller-Hennessen, Hans-Dirk Düngen, Matthias Lutz, Tobias Daniel Trippel, Michael Kreuter, Johanna Sigl, Oliver J. Müller, Elvis Tahirovic, Henning Witt, Philipp Ternes, Susan Carvalho, Erik Peter, Dietrich Rein, Philipp Schatz, Felix Herth, Evangelos Giannitsis, Tanja Weis, Norbert Frey, Hugo A. Katus

    Clinical Chemistry Jan 2017, 63 (1) 267-277; DOI: 10.1373/clinchem.2016.257279
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    Plasma N-terminal Prosomatostatin and Risk of Incident Cardiovascular Disease and All-Cause Mortality in a Prospective Observational Cohort: the PREVEND Study

    Ali Abbasi, Lyanne M. Kieneker, Eva Corpeleijn, Ron T. Gansevoort, Rijk O.B. Gans, Joachim Struck, Rudolf A. de Boer, Hans L. Hillege, Ronald P. Stolk, Gerjan Navis, Stephan J.L. Bakker

    Clinical Chemistry Jan 2017, 63 (1) 278-287; DOI: 10.1373/clinchem.2016.259275
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    A Novel Protein Glycan–Derived Inflammation Biomarker Independently Predicts Cardiovascular Disease and Modifies the Association of HDL Subclasses with Mortality

    Robert W. McGarrah, Jacob P. Kelly, Damian M. Craig, Carol Haynes, Ryan C. Jessee, Kim M. Huffman, William E. Kraus, Svati H. Shah

    Clinical Chemistry Jan 2017, 63 (1) 288-296; DOI: 10.1373/clinchem.2016.261636
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    Increased Trimethylamine N-Oxide Portends High Mortality Risk Independent of Glycemic Control in Patients with Type 2 Diabetes Mellitus

    W. H. Wilson Tang, Zeneng Wang, Xinmin S. Li, Yiying Fan, Daniel S. Li, Yuping Wu, Stanley L. Hazen

    Clinical Chemistry Jan 2017, 63 (1) 297-306; DOI: 10.1373/clinchem.2016.263640
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    High-Sensitivity Troponin I in Stable Patients with Atherosclerotic Disease in the TRA 2°P - TIMI 50 Trial

    Alon Eisen, Marc P. Bonaca, Petr Jarolim, Benjamin M. Scirica, Harvey D. White, Michal Tendera, Mikael Dellborg, Jose C. Nicolau, Joao Morais, Keith A.A. Fox, Erin A. Bohula, Sabina A. Murphy, Eugene Braunwald, David A. Morrow

    Clinical Chemistry Jan 2017, 63 (1) 307-315; DOI: 10.1373/clinchem.2016.264788

• Proteomics and Protein Markers

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    C-Type Natriuretic Peptides in Coronary Disease

    Timothy C.R. Prickett, Robert N. Doughty, Richard W. Troughton, Chris M. Frampton, Gillian A. Whalley, Chris J. Ellis, Eric A. Espiner, A. Mark Richards

    Clinical Chemistry Jan 2017, 63 (1) 316-324; DOI: 10.1373/clinchem.2016.257816
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    Growth Differentiation Factor 15 Predicts All-Cause Morbidity and Mortality in Stable Coronary Heart Disease

    Emil Hagström, Claes Held, Ralph A.H. Stewart, Philip E. Aylward, Andrzej Budaj, Christopher P. Cannon, Wolfgang Koenig, Sue Krug-Gourley, Emile R. Mohler, Philippe Gabriel Steg, Elizabeth Tarka, Ollie Östlund, Harvey D. White, Agneta Siegbahn, Lars Wallentin

    Clinical Chemistry Jan 2017, 63 (1) 325-333; DOI: 10.1373/clinchem.2016.260570
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    Association of Repeatedly Measured High-Sensitivity–Assayed Troponin I with Cardiovascular Disease Events in a General Population from the MORGAM/BiomarCaRE Study

    Maria F. Hughes, Francisco Ojeda, Olli Saarela, Torben Jørgensen, Tanja Zeller, Tarja Palosaari, Mark G. O'Doherty, Anders Borglykke, Kari Kuulasmaa, Stefan Blankenberg, Frank Kee

    Clinical Chemistry Jan 2017, 63 (1) 334-342; DOI: 10.1373/clinchem.2016.261172
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    Anti–Cardiac Troponin Autoantibodies Are Specific to the Conformational Epitopes Formed by Cardiac Troponin I and Troponin T in the Ternary Troponin Complex

    Alexandra V. Vylegzhanina, Alexander E. Kogan, Ivan A. Katrukha, Olga V. Antipova, Andrey N. Kara, Anastasia V. Bereznikova, Ekaterina V. Koshkina, Alexey G. Katrukha

    Clinical Chemistry Jan 2017, 63 (1) 343-350; DOI: 10.1373/clinchem.2016.261602
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    Specificity of B-Type Natriuretic Peptide Assays: Cross-Reactivity with Different BNP, NT-proBNP, and proBNP Peptides

    Amy K. Saenger, Olaia Rodriguez-Fraga, Ranka Ler, Jordi Ordonez-Llanos, Allan S. Jaffe, Jens Peter Goetze, Fred S. Apple

    Clinical Chemistry Jan 2017, 63 (1) 351-358; DOI: 10.1373/clinchem.2016.263749
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    Unraveling the Molecular Complexity of O-Glycosylated Endogenous (N-Terminal) pro–B-Type Natriuretic Peptide Forms in Blood Plasma of Patients with Severe Heart Failure

    Bernhard Halfinger, Angelika Hammerer-Lercher, Benno Amplatz, Bettina Sarg, Leopold Kremser, Herbert H. Lindner

    Clinical Chemistry Jan 2017, 63 (1) 359-368; DOI: 10.1373/clinchem.2016.265397
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    Rapid Rule-Out of Acute Myocardial Injury Using a Single High-Sensitivity Cardiac Troponin I Measurement

    Yader Sandoval, Stephen W. Smith, Anoop S.V. Shah, Atul Anand, Andrew R. Chapman, Sara A. Love, Karen Schulz, Jing Cao, Nicholas L. Mills, Fred S. Apple

    Clinical Chemistry Jan 2017, 63 (1) 369-376; DOI: 10.1373/clinchem.2016.264523
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    Glial Fibrillary Acidic Protein Serum Levels Distinguish between Intracerebral Hemorrhage and Cerebral Ischemia in the Early Phase of Stroke

    Sebastian Luger, Jens Witsch, Andreas Dietz, Gerhard F. Hamann, Jens Minnerup, Hauke Schneider, Matthias Sitzer, Katja E. Wartenberg, Marion Niessner, Christian Foerch

    Clinical Chemistry Jan 2017, 63 (1) 377-385; DOI: 10.1373/clinchem.2016.263335
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    Soluble CD146 Is a Novel Marker of Systemic Congestion in Heart Failure Patients: An Experimental Mechanistic and Transcardiac Clinical Study

    Mattia Arrigo, Quynh A. Truong, Duygu Onat, Jackie Szymonifka, Etienne Gayat, Heli Tolppanen, Malha Sadoune, Ryan T. Demmer, Ka Y. Wong, Jean Marie Launay, Jane-Lise Samuel, Alain Cohen-Solal, James L. Januzzi, Jagmeet P. Singh, Paolo C. Colombo, Alexandre Mebazaa

    Clinical Chemistry Jan 2017, 63 (1) 386-393; DOI: 10.1373/clinchem.2016.260471
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    Immediate Rule-Out of Acute Myocardial Infarction Using Electrocardiogram and Baseline High-Sensitivity Troponin I

    Johannes Tobias Neumann, Nils Arne Sörensen, Francisco Ojeda, Tjark Schwemer, Jonas Lehmacher, Saskia Gönner, Nikolas Jarsetz, Till Keller, Sarina Schaefer, Thomas Renné, Ulf Landmesser, Peter Clemmensen, Nataliya Makarova, Renate B. Schnabel, Tanja Zeller, Mahir Karakas, John W. Pickering, Martin Than, William Parsonage, Jaimi Greenslade, Louise Cullen, Dirk Westermann, Stefan Blankenberg

    Clinical Chemistry Jan 2017, 63 (1) 394-402; DOI: 10.1373/clinchem.2016.262659

• Evidence-Based Medicine and Test Utilization

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    Rule-In and Rule-Out of Myocardial Infarction Using Cardiac Troponin and Glycemic Biomarkers in Patients with Symptoms Suggestive of Acute Coronary Syndrome

    Colleen Shortt, Jinhui Ma, Natasha Clayton, Jonathan Sherbino, Richard Whitlock, Guillaume Pare, Stephen A. Hill, Matthew McQueen, Shamir R. Mehta, P.J. Devereaux, Andrew Worster, Peter A. Kavsak

    Clinical Chemistry Jan 2017, 63 (1) 403-414; DOI: 10.1373/clinchem.2016.261545

• Other Areas of Clinical Chemistry

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    Discordance between ICD-Coded Myocardial Infarction and Diagnosis according to the Universal Definition of Myocardial Infarction

    Jorge Díaz-Garzón, Yader Sandoval, Stephen W. Smith, Sara Love, Karen Schulz, Sarah E. Thordsen, Benjamin K. Johnson, Brian Driver, Katherine Jacoby, Michelle D. Carlson, Kenneth W. Dodd, Johanna Moore, Nathaniel L. Scott, Charles A. Bruen, Ryan Hatch, Fred S. Apple

    Clinical Chemistry Jan 2017, 63 (1) 415-419; DOI: 10.1373/clinchem.2016.263764
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    Trimethylamine N-oxide and Risk Stratification after Acute Myocardial Infarction

    Toru Suzuki, Liam M. Heaney, Donald J. L. Jones, Leong L. Ng

    Clinical Chemistry Jan 2017, 63 (1) 420-428; DOI: 10.1373/clinchem.2016.264853