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Clinical Chemistry

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Table of Contents

January 2015; volume 61, issue 1

Preamble

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    Molecular Diagnostics: A Revolution in Progress
    Rossa W.K. Chiu, Y.M. Dennis Lo, Carl T. Wittwer
    Clinical Chemistry Jan 2015, 61 (1) 1-3; DOI: 10.1373/clinchem.2014.233361

Editorials

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    Taking It to the Extreme: PCR at Wittwerspeed
    John F. Mackay
    Clinical Chemistry Jan 2015, 61 (1) 4-5; DOI: 10.1373/clinchem.2014.233338
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    Sorting the Wheat from the Chaff in Familial Hypercholesterolemia
    Amanda J. Hooper, Gerald F. Watts
    Clinical Chemistry Jan 2015, 61 (1) 6-8; DOI: 10.1373/clinchem.2014.234609

Interview

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    An Interview with Bert Vogelstein and Kenneth Kinzler
    Misia Landau
    Clinical Chemistry Jan 2015, 61 (1) 9-20; DOI: 10.1373/clinchem.2014.223271

Reflections

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    Solexa Sequencing: Decoding Genomes on a Population Scale
    Shankar Balasubramanian
    Clinical Chemistry Jan 2015, 61 (1) 21-24; DOI: 10.1373/clinchem.2014.221747
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    Nanopore Sequencing: From Imagination to Reality
    Hagan Bayley
    Clinical Chemistry Jan 2015, 61 (1) 25-31; DOI: 10.1373/clinchem.2014.223016
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    Noninvasive Prenatal Diagnosis: From Dream to Reality
    Y. M. Dennis Lo
    Clinical Chemistry Jan 2015, 61 (1) 32-37; DOI: 10.1373/clinchem.2014.223024

Perspective

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    Actionable Sequence Data on Infectious Diseases in the Clinical Workplace
    David A. Relman
    Clinical Chemistry Jan 2015, 61 (1) 38-40; DOI: 10.1373/clinchem.2014.229211

Q&A

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    Next Generation Sequencing in Clinical Diagnostics: Experiences of Early Adopters
    Elaine Lyon, Franklin R. Cockerill, Sherri J. Bale, Carol Beadling, Lynn Bry, Jill Hagenkord, Shashikant Kulkarni, Richard Press, Glenn E. Palomaki
    Clinical Chemistry Jan 2015, 61 (1) 41-49; DOI: 10.1373/clinchem.2014.222687

Clinical Case Study

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    A 5-Month-Old Boy with Delay in Growth and Development and Decreased Muscle Tone
    Vishwanathan Hucthagowder, Marwan Shinawi, Christina M. Lockwood
    Clinical Chemistry Jan 2015, 61 (1) 50-54; DOI: 10.1373/clinchem.2014.228486
  • Commentaries

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      Commentary
      Wen-Hann Tan
      Clinical Chemistry Jan 2015, 61 (1) 54; DOI: 10.1373/clinchem.2014.232934
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      Commentary
      Merlin G. Butler
      Clinical Chemistry Jan 2015, 61 (1) 55; DOI: 10.1373/clinchem.2014.232942

Mini-Reviews

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    Circulating MicroRNA Biomarker Studies: Pitfalls and Potential Solutions
    Kenneth W. Witwer
    Clinical Chemistry Jan 2015, 61 (1) 56-63; DOI: 10.1373/clinchem.2014.221341
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    Sequence Artifacts in DNA from Formalin-Fixed Tissues: Causes and Strategies for Minimization
    Hongdo Do, Alexander Dobrovic
    Clinical Chemistry Jan 2015, 61 (1) 64-71; DOI: 10.1373/clinchem.2014.223040
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    Quantitative Nucleic Acid Amplification Methods for Viral Infections
    Jonathan C. Gullett, Frederick S. Nolte
    Clinical Chemistry Jan 2015, 61 (1) 72-78; DOI: 10.1373/clinchem.2014.223289

Reviews

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    Considerations for Digital PCR as an Accurate Molecular Diagnostic Tool
    Jim F. Huggett, Simon Cowen, Carole A. Foy
    Clinical Chemistry Jan 2015, 61 (1) 79-88; DOI: 10.1373/clinchem.2014.221366
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    DNA/RNA Preparation for Molecular Detection
    Stephanie A. Thatcher
    Clinical Chemistry Jan 2015, 61 (1) 89-99; DOI: 10.1373/clinchem.2014.221374
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    MALDI-TOF MS for the Diagnosis of Infectious Diseases
    Robin Patel
    Clinical Chemistry Jan 2015, 61 (1) 100-111; DOI: 10.1373/clinchem.2014.221770
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    Circulating Tumor DNA as a Liquid Biopsy for Cancer
    Ellen Heitzer, Peter Ulz, Jochen B. Geigl
    Clinical Chemistry Jan 2015, 61 (1) 112-123; DOI: 10.1373/clinchem.2014.222679
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    Bioinformatics for Clinical Next Generation Sequencing
    Gavin R. Oliver, Steven N. Hart, Eric W. Klee
    Clinical Chemistry Jan 2015, 61 (1) 124-135; DOI: 10.1373/clinchem.2014.224360

Opinions

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    Reimbursement in Molecular Pathology: Bringing Genomic Medicine to Patients
    Roger D. Klein
    Clinical Chemistry Jan 2015, 61 (1) 136-138; DOI: 10.1373/clinchem.2014.223032
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    Consenting for Molecular Diagnostics
    Robert Klitzman
    Clinical Chemistry Jan 2015, 61 (1) 139-141; DOI: 10.1373/clinchem.2014.223404
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    Comparative Effectiveness Research and Demonstrating Clinical Utility for Molecular Diagnostic Tests
    Patricia A. Deverka, Susanne B. Haga
    Clinical Chemistry Jan 2015, 61 (1) 142-144; DOI: 10.1373/clinchem.2014.223412

Articles

  • Molecular Diagnostics and Genetics

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      Extreme PCR: Efficient and Specific DNA Amplification in 15–60 Seconds
      Jared S. Farrar, Carl T. Wittwer
      Clinical Chemistry Jan 2015, 61 (1) 145-153; DOI: 10.1373/clinchem.2014.228304
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      Translating Sanger-Based Routine DNA Diagnostics into Generic Massive Parallel Ion Semiconductor Sequencing
      Adinda Diekstra, Ermanno Bosgoed, Alwin Rikken, Bart van Lier, Erik-Jan Kamsteeg, Marloes Tychon, Ronny C. Derks, Ronald A. van Soest, Arjen R. Mensenkamp, Hans Scheffer, Kornelia Neveling, Marcel R. Nelen
      Clinical Chemistry Jan 2015, 61 (1) 154-162; DOI: 10.1373/clinchem.2014.225250
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      DNA Ligase-Based Strategy for Quantifying Heterogeneous DNA Methylation without Sequencing
      Eugene J.H. Wee, Sakandar Rauf, Muhammad J.A. Shiddiky, Alexander Dobrovic, Matt Trau
      Clinical Chemistry Jan 2015, 61 (1) 163-171; DOI: 10.1373/clinchem.2014.227546
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      Noninvasive Prenatal Testing for Wilson Disease by Use of Circulating Single-Molecule Amplification and Resequencing Technology (cSMART)
      Weigang Lv, Xianda Wei, Ruolan Guo, Qin Liu, Yu Zheng, Jiazhen Chang, Ting Bai, Haoxian Li, Jianguang Zhang, Zhuo Song, David S. Cram, Desheng Liang, Lingqian Wu
      Clinical Chemistry Jan 2015, 61 (1) 172-181; DOI: 10.1373/clinchem.2014.229328
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      Screening Newborn Blood Spots for 22q11.2 Deletion Syndrome Using Multiplex Droplet Digital PCR
      Dalyir Pretto, Dianna Maar, Carolyn M. Yrigollen, Jack Regan, Flora Tassone
      Clinical Chemistry Jan 2015, 61 (1) 182-190; DOI: 10.1373/clinchem.2014.230086
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      Circulating Long Noncoding RNA TapSAKI Is a Predictor of Mortality in Critically Ill Patients with Acute Kidney Injury
      Johan M. Lorenzen, Celina Schauerte, Jan T. Kielstein, Anika Hübner, Filippo Martino, Jan Fiedler, Shashi K. Gupta, Robert Faulhaber-Walter, Regalla Kumarswamy, Carsten Hafer, Hermann Haller, Danilo Fliser, Thomas Thum
      Clinical Chemistry Jan 2015, 61 (1) 191-201; DOI: 10.1373/clinchem.2014.230359
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      Variability of the Reverse Transcription Step: Practical Implications
      Stephen Bustin, Harvinder S. Dhillon, Sara Kirvell, Christina Greenwood, Michael Parker, Gregory L. Shipley, Tania Nolan
      Clinical Chemistry Jan 2015, 61 (1) 202-212; DOI: 10.1373/clinchem.2014.230615
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      Clinical Exome Performance for Reporting Secondary Genetic Findings
      Jason Y. Park, Peter Clark, Eric Londin, Marialuisa Sponziello, Larry J. Kricka, Paolo Fortina
      Clinical Chemistry Jan 2015, 61 (1) 213-220; DOI: 10.1373/clinchem.2014.231456
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      The Landscape of MicroRNA, Piwi-Interacting RNA, and Circular RNA in Human Saliva
      Jae Hoon Bahn, Qing Zhang, Feng Li, Tak-Ming Chan, Xianzhi Lin, Yong Kim, David T.W. Wong, Xinshu Xiao
      Clinical Chemistry Jan 2015, 61 (1) 221-230; DOI: 10.1373/clinchem.2014.230433
  • Lipids, Lipoproteins, and Cardiovascular Risk Factors

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      Refinement of Variant Selection for the LDL Cholesterol Genetic Risk Score in the Diagnosis of the Polygenic Form of Clinical Familial Hypercholesterolemia and Replication in Samples from 6 Countries
      Marta Futema, Sonia Shah, Jackie A. Cooper, KaWah Li, Ros A. Whittall, Mahtab Sharifi, Olivia Goldberg, Euridiki Drogari, Vasiliki Mollaki, Albert Wiegman, Joep Defesche, Maria N. D'Agostino, Antonietta D'Angelo, Paolo Rubba, Giuliana Fortunato, Małgorzata Waluś-Miarka, Robert A. Hegele, Mary Aderayo Bamimore, Ronen Durst, Eran Leitersdorf, Monique T. Mulder, Jeanine E. Roeters van Lennep, Eric J.G. Sijbrands, John C. Whittaker, Philippa J. Talmud, Steve E. Humphries
      Clinical Chemistry Jan 2015, 61 (1) 231-238; DOI: 10.1373/clinchem.2014.231365
  • Cancer Diagnostics

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      Chromosomal Instability in Cell-Free DNA Is a Serum Biomarker for Prostate Cancer
      Ekkehard Schütz, Mohammad R. Akbari, Julia Beck, Howard Urnovitz, William W. Zhang, Kirsten Bornemann-Kolatzki, William M. Mitchell, Robert K. Nam, Steven A. Narod
      Clinical Chemistry Jan 2015, 61 (1) 239-248; DOI: 10.1373/clinchem.2014.226571
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      Validation of DNA Methylation to Predict Outcome in Acute Myeloid Leukemia by Use of xMELP
      Gerald B.W. Wertheim, Catherine Smith, Marlise Luskin, Alison Rager, Maria E. Figueroa, Martin Carroll, Stephen R. Master
      Clinical Chemistry Jan 2015, 61 (1) 249-258; DOI: 10.1373/clinchem.2014.229781
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      Circulating Tumor Cell Enumeration with a Combination of Epithelial Cell Adhesion Molecule– and Cell-Surface Vimentin–Based Methods for Monitoring Breast Cancer Therapeutic Response
      Arun Satelli, Zachary Brownlee, Abhisek Mitra, Qing H. Meng, Shulin Li
      Clinical Chemistry Jan 2015, 61 (1) 259-266; DOI: 10.1373/clinchem.2014.228122
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      Single-Tube, Highly Parallel Mutation Enrichment in Cancer Gene Panels by Use of Temperature-Tolerant COLD-PCR
      Elena Castellanos-Rizaldos, Katherine Richardson, Rui Lin, Grant Wu, Mike G. Makrigiorgos
      Clinical Chemistry Jan 2015, 61 (1) 267-277; DOI: 10.1373/clinchem.2014.228361
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      Gene Expression Profiling of Circulating Tumor Cells in Breast Cancer
      Emanuela Fina, Maurizio Callari, Carolina Reduzzi, Francesca D'Aiuto, Gabriella Mariani, Daniele Generali, Marco A. Pierotti, Maria G. Daidone, Vera Cappelletti
      Clinical Chemistry Jan 2015, 61 (1) 278-289; DOI: 10.1373/clinchem.2014.229476
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      Next Generation Digital PCR Measurement of Hepatitis B Virus Copy Number in Formalin-Fixed Paraffin-Embedded Hepatocellular Carcinoma Tissue
      Jing-Tao Huang, Ying-Juan Liu, Jin Wang, Zhi-Gao Xu, Ying Yang, Fan Shen, Xing-hui Liu, Xin Zhou, Song-Mei Liu
      Clinical Chemistry Jan 2015, 61 (1) 290-296; DOI: 10.1373/clinchem.2014.230227
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      Quantitative Cell-Free Circulating BRAFV600E Mutation Analysis by Use of Droplet Digital PCR in the Follow-up of Patients with Melanoma Being Treated with BRAF Inhibitors
      Miguel F. Sanmamed, Sara Fernández-Landázuri, Carmen Rodríguez, Ruth Zárate, María D. Lozano, Leyre Zubiri, José Luis Perez-Gracia, Salvador Martín-Algarra, Alvaro González
      Clinical Chemistry Jan 2015, 61 (1) 297-304; DOI: 10.1373/clinchem.2014.230235

Citation Classic

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    Accurate Whole Genome Sequencing as the Ultimate Genetic Test
    Radoje Drmanac, Brock A. Peters, George M. Church, Clifford A. Reid, Xun Xu
    Clinical Chemistry Jan 2015, 61 (1) 305-306; DOI: 10.1373/clinchem.2014.224907

Clinical Chemist

  • News & Views

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      Genetic Data in Health Care: From Data to Information
      Deborah French, Thomas Kampfrath
      Clinical Chemistry Jan 2015, 61 (1) 307; DOI: 10.1373/clinchem.2014.230649
  • Unveiling the Right Side

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      My Native State
      Usha Anand
      Clinical Chemistry Jan 2015, 61 (1) 308-310; DOI: 10.1373/clinchem.2014.225201
  • Science in the Arts

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      Linear Perspective: A Visual Revolution
      Marek H. Dominiczak
      Clinical Chemistry Jan 2015, 61 (1) 311-312; DOI: 10.1373/clinchem.2014.226340
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In this issue

Clinical Chemistry: 61 (1)
Vol. 61, Issue 1
January 2015
  • Table of Contents
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