Table of Contents

Articles

• Molecular Diagnostics and Genetics

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    Extreme PCR: Efficient and Specific DNA Amplification in 15–60 Seconds

    Jared S. Farrar, Carl T. Wittwer

    Clinical Chemistry Jan 2015, 61 (1) 145-153; DOI: 10.1373/clinchem.2014.228304
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    Translating Sanger-Based Routine DNA Diagnostics into Generic Massive Parallel Ion Semiconductor Sequencing

    Adinda Diekstra, Ermanno Bosgoed, Alwin Rikken, Bart van Lier, Erik-Jan Kamsteeg, Marloes Tychon, Ronny C. Derks, Ronald A. van Soest, Arjen R. Mensenkamp, Hans Scheffer, Kornelia Neveling, Marcel R. Nelen

    Clinical Chemistry Jan 2015, 61 (1) 154-162; DOI: 10.1373/clinchem.2014.225250
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    DNA Ligase-Based Strategy for Quantifying Heterogeneous DNA Methylation without Sequencing

    Eugene J.H. Wee, Sakandar Rauf, Muhammad J.A. Shiddiky, Alexander Dobrovic, Matt Trau

    Clinical Chemistry Jan 2015, 61 (1) 163-171; DOI: 10.1373/clinchem.2014.227546
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    Noninvasive Prenatal Testing for Wilson Disease by Use of Circulating Single-Molecule Amplification and Resequencing Technology (cSMART)

    Weigang Lv, Xianda Wei, Ruolan Guo, Qin Liu, Yu Zheng, Jiazhen Chang, Ting Bai, Haoxian Li, Jianguang Zhang, Zhuo Song, David S. Cram, Desheng Liang, Lingqian Wu

    Clinical Chemistry Jan 2015, 61 (1) 172-181; DOI: 10.1373/clinchem.2014.229328
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    Screening Newborn Blood Spots for 22q11.2 Deletion Syndrome Using Multiplex Droplet Digital PCR

    Dalyir Pretto, Dianna Maar, Carolyn M. Yrigollen, Jack Regan, Flora Tassone

    Clinical Chemistry Jan 2015, 61 (1) 182-190; DOI: 10.1373/clinchem.2014.230086
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    Circulating Long Noncoding RNA TapSAKI Is a Predictor of Mortality in Critically Ill Patients with Acute Kidney Injury

    Johan M. Lorenzen, Celina Schauerte, Jan T. Kielstein, Anika Hübner, Filippo Martino, Jan Fiedler, Shashi K. Gupta, Robert Faulhaber-Walter, Regalla Kumarswamy, Carsten Hafer, Hermann Haller, Danilo Fliser, Thomas Thum

    Clinical Chemistry Jan 2015, 61 (1) 191-201; DOI: 10.1373/clinchem.2014.230359
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    Variability of the Reverse Transcription Step: Practical Implications

    Stephen Bustin, Harvinder S. Dhillon, Sara Kirvell, Christina Greenwood, Michael Parker, Gregory L. Shipley, Tania Nolan

    Clinical Chemistry Jan 2015, 61 (1) 202-212; DOI: 10.1373/clinchem.2014.230615
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    Clinical Exome Performance for Reporting Secondary Genetic Findings

    Jason Y. Park, Peter Clark, Eric Londin, Marialuisa Sponziello, Larry J. Kricka, Paolo Fortina

    Clinical Chemistry Jan 2015, 61 (1) 213-220; DOI: 10.1373/clinchem.2014.231456
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    The Landscape of MicroRNA, Piwi-Interacting RNA, and Circular RNA in Human Saliva

    Jae Hoon Bahn, Qing Zhang, Feng Li, Tak-Ming Chan, Xianzhi Lin, Yong Kim, David T.W. Wong, Xinshu Xiao

    Clinical Chemistry Jan 2015, 61 (1) 221-230; DOI: 10.1373/clinchem.2014.230433

• Lipids, Lipoproteins, and Cardiovascular Risk Factors

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    Refinement of Variant Selection for the LDL Cholesterol Genetic Risk Score in the Diagnosis of the Polygenic Form of Clinical Familial Hypercholesterolemia and Replication in Samples from 6 Countries

    Marta Futema, Sonia Shah, Jackie A. Cooper, KaWah Li, Ros A. Whittall, Mahtab Sharifi, Olivia Goldberg, Euridiki Drogari, Vasiliki Mollaki, Albert Wiegman, Joep Defesche, Maria N. D'Agostino, Antonietta D'Angelo, Paolo Rubba, Giuliana Fortunato, Małgorzata Waluś-Miarka, Robert A. Hegele, Mary Aderayo Bamimore, Ronen Durst, Eran Leitersdorf, Monique T. Mulder, Jeanine E. Roeters van Lennep, Eric J.G. Sijbrands, John C. Whittaker, Philippa J. Talmud, Steve E. Humphries

    Clinical Chemistry Jan 2015, 61 (1) 231-238; DOI: 10.1373/clinchem.2014.231365

• Cancer Diagnostics

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    Chromosomal Instability in Cell-Free DNA Is a Serum Biomarker for Prostate Cancer

    Ekkehard Schütz, Mohammad R. Akbari, Julia Beck, Howard Urnovitz, William W. Zhang, Kirsten Bornemann-Kolatzki, William M. Mitchell, Robert K. Nam, Steven A. Narod

    Clinical Chemistry Jan 2015, 61 (1) 239-248; DOI: 10.1373/clinchem.2014.226571
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    Validation of DNA Methylation to Predict Outcome in Acute Myeloid Leukemia by Use of xMELP

    Gerald B.W. Wertheim, Catherine Smith, Marlise Luskin, Alison Rager, Maria E. Figueroa, Martin Carroll, Stephen R. Master

    Clinical Chemistry Jan 2015, 61 (1) 249-258; DOI: 10.1373/clinchem.2014.229781
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    Circulating Tumor Cell Enumeration with a Combination of Epithelial Cell Adhesion Molecule– and Cell-Surface Vimentin–Based Methods for Monitoring Breast Cancer Therapeutic Response

    Arun Satelli, Zachary Brownlee, Abhisek Mitra, Qing H. Meng, Shulin Li

    Clinical Chemistry Jan 2015, 61 (1) 259-266; DOI: 10.1373/clinchem.2014.228122
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    Single-Tube, Highly Parallel Mutation Enrichment in Cancer Gene Panels by Use of Temperature-Tolerant COLD-PCR

    Elena Castellanos-Rizaldos, Katherine Richardson, Rui Lin, Grant Wu, Mike G. Makrigiorgos

    Clinical Chemistry Jan 2015, 61 (1) 267-277; DOI: 10.1373/clinchem.2014.228361
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    Gene Expression Profiling of Circulating Tumor Cells in Breast Cancer

    Emanuela Fina, Maurizio Callari, Carolina Reduzzi, Francesca D'Aiuto, Gabriella Mariani, Daniele Generali, Marco A. Pierotti, Maria G. Daidone, Vera Cappelletti

    Clinical Chemistry Jan 2015, 61 (1) 278-289; DOI: 10.1373/clinchem.2014.229476
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    Next Generation Digital PCR Measurement of Hepatitis B Virus Copy Number in Formalin-Fixed Paraffin-Embedded Hepatocellular Carcinoma Tissue

    Jing-Tao Huang, Ying-Juan Liu, Jin Wang, Zhi-Gao Xu, Ying Yang, Fan Shen, Xing-hui Liu, Xin Zhou, Song-Mei Liu

    Clinical Chemistry Jan 2015, 61 (1) 290-296; DOI: 10.1373/clinchem.2014.230227
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    Quantitative Cell-Free Circulating BRAF^V600E Mutation Analysis by Use of Droplet Digital PCR in the Follow-up of Patients with Melanoma Being Treated with BRAF Inhibitors

    Miguel F. Sanmamed, Sara Fernández-Landázuri, Carmen Rodríguez, Ruth Zárate, María D. Lozano, Leyre Zubiri, José Luis Perez-Gracia, Salvador Martín-Algarra, Alvaro González

    Clinical Chemistry Jan 2015, 61 (1) 297-304; DOI: 10.1373/clinchem.2014.230235