Clinical Chemistry: 60 (5)

May 2014; volume 60, issue 5

Editorials

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Genetically Low Triglycerides and Mortality: Further Support for “the Earlier the Better”?
Seth S. Martin, Michael J. Blaha

Clinical Chemistry May 2014, 60 (5) 705-707; DOI: 10.1373/clinchem.2013.220970
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myo-Inositol Oxygenase: A Novel Kidney-Specific Biomarker of Acute Kidney Injury?
Ana Konvalinka

Clinical Chemistry May 2014, 60 (5) 708-710; DOI: 10.1373/clinchem.2014.221960

Perspective

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When a “Disease-Causing Mutation” Is Not a Pathogenic Variant
Jian Wang, Yiping Shen

Clinical Chemistry May 2014, 60 (5) 711-713; DOI: 10.1373/clinchem.2013.215947

Q&A

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Interferon γ–Release Assays for Diagnosis of Latent Tuberculosis in Healthcare Workers in Low-Incidence Settings: Pros and Cons
Nira R. Pollock, Alexander J. McAdam, Madhukar Pai, Edward A. Nardell, John Bernardo, Niaz Banaei, Jay Mobo

Clinical Chemistry May 2014, 60 (5) 714-718; DOI: 10.1373/clinchem.2012.201178

Clinical Case Study

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A Neonatal Agranulocytosis
Hervé Delacour, Pierre Mornand, Sébastien Larréché, Jean Etienne Pilo, Audrey Mérens, Patrick Imbert

Clinical Chemistry May 2014, 60 (5) 719-722; DOI: 10.1373/clinchem.2013.202705
Commentaries
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  Commentary
  Lori Luchtman-Jones
  
  Clinical Chemistry May 2014, 60 (5) 722-723; DOI: 10.1373/clinchem.2013.220640
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  Commentary
  Edward C.C. Wong
  
  Clinical Chemistry May 2014, 60 (5) 723; DOI: 10.1373/clinchem.2013.210880

Review

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Whole Genome Sequencing as a Diagnostic Test: Challenges and Opportunities
Caitlin C. Chrystoja, Eleftherios P. Diamandis

Clinical Chemistry May 2014, 60 (5) 724-733; DOI: 10.1373/clinchem.2013.209213

Opinion

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Is It Time to Do Away With the 99th Percentile for Cardiac Troponin in the Diagnosis of Acute Coronary Syndrome and the Assessment of Cardiac Risk?
Peter E. Hickman, Bertil Lindahl, Julia M. Potter, Per Venge, Gus Koerbin, Kai M. Eggers

Clinical Chemistry May 2014, 60 (5) 734-736; DOI: 10.1373/clinchem.2013.217711

Articles

Lipids, Lipoproteins, and Cardiovascular Risk Factors
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  Low Nonfasting Triglycerides and Reduced All-Cause Mortality: A Mendelian Randomization Study
  Mette Thomsen, Anette Varbo, Anne Tybjærg-Hansen, Børge G. Nordestgaard
  
  Clinical Chemistry May 2014, 60 (5) 737-746; DOI: 10.1373/clinchem.2013.219881
Proteomics and Protein Markers
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  Development of an Immunoassay for the Kidney-Specific Protein myo-Inositol Oxygenase, a Potential Biomarker of Acute Kidney Injury
  Joseph P. Gaut, Dan L. Crimmins, Matt F. Ohlendorf, Christina M. Lockwood, Terry A. Griest, Nancy A. Brada, Masato Hoshi, Bryan Sato, Richard S. Hotchkiss, Sanjay Jain, Jack H. Ladenson
  
  Clinical Chemistry May 2014, 60 (5) 747-757; DOI: 10.1373/clinchem.2013.212993
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  Reference Interval Evaluation of High-Sensitivity Troponin T and N-Terminal B-Type Natriuretic Peptide in Vietnam and the US: The North South East West Trial
  Hanna K. Gaggin, Phuoc V. Dang, Loi D. Do, Christopher R. deFilippi, Robert H. Christenson, Elizabeth L. Lewandrowski, Kent B. Lewandrowski, Binh Q. Truong, Vinh Q. Pham, Vu H. Vu, Truong V. Vu, Toan B. Nguyen, Arianna M. Belcher, Alexandra Femia, Cynthia Kelley, James L. Januzzi
  
  Clinical Chemistry May 2014, 60 (5) 758-764; DOI: 10.1373/clinchem.2013.216275
Molecular Diagnostics and Genetics
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  Identification of Chromosomally Integrated Human Herpesvirus 6 by Droplet Digital PCR
  Ruth Hall Sedlak, Linda Cook, Meei-Li Huang, Amalia Magaret, Danielle M. Zerr, Michael Boeckh, Keith R. Jerome
  
  Clinical Chemistry May 2014, 60 (5) 765-772; DOI: 10.1373/clinchem.2013.217240
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  Profiling Plasma MicroRNA in Nasopharyngeal Carcinoma with Deep Sequencing
  Hai-Yun Wang, Li-Xu Yan, Qiong Shao, Sha Fu, Zi-Chen Zhang, Weimin Ye, Yi-Xin Zeng, Jian-Yong Shao
  
  Clinical Chemistry May 2014, 60 (5) 773-782; DOI: 10.1373/clinchem.2013.214213
Endocrinology and Metabolism
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  Liquid Chromatography–Tandem Mass Spectrometry Enzyme Assay for UDP-Galactose 4′-Epimerase: Use of Fragment Intensity Ratio in Differentiation of Structural Isomers
  Yijun Li, Xiaoping Huang, Lauren Harmonay, Ying Liu, Mark D. Kellogg, Judith L. Fridovich-Keil, Gerard T. Berry
  
  Clinical Chemistry May 2014, 60 (5) 783-790; DOI: 10.1373/clinchem.2013.219931

Citation Classic

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Herpesviruses Encode Their Own MicroRNAs
Sébastien Pfeffer

Clinical Chemistry May 2014, 60 (5) 791-792; DOI: 10.1373/clinchem.2013.216408

Clinical Chemist

What is Your Guess?
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  Which Protein Bands Are Significant?
  Ross Miller, Alina-Gabriela Sofronescu
  
  Clinical Chemistry May 2014, 60 (5) 793-794; DOI: 10.1373/clinchem.2013.211888
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  Where Has All the β₁-Transferrin Gone?
  Yu Chen, James Samsoondar, Liju Yang
  
  Clinical Chemistry May 2014, 60 (5) 794-795; DOI: 10.1373/clinchem.2013.216606
News & Views
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  Personalized Therapeutics and Companion Diagnostics: A New Paradigm in Testing and Treatment
  Nicholas E. Heger, Mark D. Kellogg
  
  Clinical Chemistry May 2014, 60 (5) 795-796; DOI: 10.1373/clinchem.2013.220228
The Best of Clinical Chemistry
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  Clinical Chemistry Has It Covered!
  Clinical Chemistry May 2014, 60 (5) 797;
Unveiling the Right Side
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  Interpretation of Alvin Coburn's The Bridge, Venice in Pen and Ink
  Nader Rifai
  
  Clinical Chemistry May 2014, 60 (5) 798-799; DOI: 10.1373/clinchem.2014.223297
Science in the Arts
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  Physicians, Scientists, and the Wider Culture: Sir William Osler
  Marek H. Dominiczak
  
  Clinical Chemistry May 2014, 60 (5) 800-801; DOI: 10.1373/clinchem.2013.218297

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Table of Contents

Editorials

Perspective

Q&A

Clinical Case Study

Commentaries

Review

Opinion

Articles

Lipids, Lipoproteins, and Cardiovascular Risk Factors

Proteomics and Protein Markers

Molecular Diagnostics and Genetics

Endocrinology and Metabolism

Citation Classic

Clinical Chemist

What is Your Guess?

News & Views

The Best of Clinical Chemistry

Unveiling the Right Side

Science in the Arts

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