Skip to main content

Main menu

  • Home
  • About
    • Clinical Chemistry
    • Editorial Board
    • Most Read
    • Most Cited
    • Alerts
    • CE Credits
  • Articles
    • Current Issue
    • Early Release
    • Future Table of Contents
    • Archive
    • Browse by Subject
  • Info for
    • Authors
    • Reviewers
    • Subscribers
    • Advertisers
    • Permissions & Reprints
  • Resources
    • AACC Learning Lab
    • Clinical Chemistry Trainee Council
    • Clinical Case Studies
    • Clinical Chemistry Guide to Scientific Writing
    • Clinical Chemistry Guide to Manuscript Review
    • Journal Club
    • Podcasts
    • Q&A
    • Translated Content
  • Abstracts
  • Submit
  • Contact
  • Other Publications
    • The Journal of Applied Laboratory Medicine

User menu

  • Subscribe
  • My alerts
  • Log in

Search

  • Advanced search
Clinical Chemistry
  • Other Publications
    • The Journal of Applied Laboratory Medicine
  • Subscribe
  • My alerts
  • Log in
Clinical Chemistry

Advanced Search

  • Home
  • About
    • Clinical Chemistry
    • Editorial Board
    • Most Read
    • Most Cited
    • Alerts
    • CE Credits
  • Articles
    • Current Issue
    • Early Release
    • Future Table of Contents
    • Archive
    • Browse by Subject
  • Info for
    • Authors
    • Reviewers
    • Subscribers
    • Advertisers
    • Permissions & Reprints
  • Resources
    • AACC Learning Lab
    • Clinical Chemistry Trainee Council
    • Clinical Case Studies
    • Clinical Chemistry Guide to Scientific Writing
    • Clinical Chemistry Guide to Manuscript Review
    • Journal Club
    • Podcasts
    • Q&A
    • Translated Content
  • Abstracts
  • Submit
  • Contact
OtherBook, Software, and Web Site Reviews

Clinical Toxicology: Principles and Mechanisms. Frank A. Barile. Boca Raton, FL: CRC Press, 2004, 474 pp., $79.95, hardcover. ISBN-0-8493-1582-4.

Christopher P. Holstege
DOI: 10.1373/clinchem.2004.034611 Published March 2005
Christopher P. Holstege
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

The field of clinical toxicology has grown dramatically over the last few decades. Along with that growth have come numerous publications pertaining to this field. Part one of this book addresses the basic toxicologic principles and provides a brief overview of basic toxicologic definitions, regulatory bodies, and toxicokinetics. Parts two and three of this book provide overviews of the toxicities of therapeutic and nontherapeutic agents, respectively.

I commend the author for the inclusion of a diverse group of nontherapeutic agents. The current clinical toxicology books available on the market tend to focus on the therapeutic agents, with nontherapeutic agents briefly added. This book addresses many unique nontherapeutic agents that may be encountered by the clinician. The format is concise and clear so that information can be gleaned rapidly by those perusing this book. The charts found within this book add greatly and also allow quick review of information.

The greatest weakness of this book, ironically, is in its discussion of clinical management. Each specific toxin mentioned has an associated well-written, concise review of its pharmacology and mechanism of toxicity, but the discussion pertaining to the clinical management of specific toxicities is often too brief, and at times too antiquated, to be useful clinically in the management of patients manifesting signs of toxicity. For example, the chapter on calcium channel blockers glosses over only a few of the recommended therapies. Other therapies available to the clinician for the treatment of calcium channel blocker overdose, such as sodium bicarbonate and insulin, are not mentioned and yet are important to consider in the treatment of these poisonings. In another example, the author advocates that syrup of ipecac “should be part of all household medicine cabinets”. The majority of clinical toxicologists over the past decade have actually withdrawn their support of syrup of ipecac in the management of poisonings. In 2003, the American Academy of Pediatrics issued a statement that “ipecac should no longer be used routinely as a home treatment strategy, that existing ipecac in the home should be disposed of safely.” (Pediatrics 2003;112:1182–5). For clinicians using this book for the management of patients manifesting signs of toxicity, the limited scope of the clinical management sections could lead to incomplete therapy.

Figure 1.
  • Download figure
  • Open in new tab
Figure 1.
  • © 2005 The American Association for Clinical Chemistry
View Abstract
PreviousNext
Back to top

In this issue

Clinical Chemistry: 51 (4)
Vol. 51, Issue 4
April 2005
  • Table of Contents
  • Index by author
Print
Share
Clinical Toxicology: Principles and Mechanisms. Frank A. Barile. Boca Raton, FL: CRC Press, 2004, 474 pp., $79.95, hardcover. ISBN-0-8493-1582-4.
Christopher P. Holstege
Clinical Chemistry Apr 2005, 51 (4) 795-796; DOI: 10.1373/clinchem.2004.034611
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Article Alerts
Sign In to Email Alerts with your Email Address
Citation Tools
Clinical Toxicology: Principles and Mechanisms. Frank A. Barile. Boca Raton, FL: CRC Press, 2004, 474 pp., $79.95, hardcover. ISBN-0-8493-1582-4.
Christopher P. Holstege
Clinical Chemistry Apr 2005, 51 (4) 795-796; DOI: 10.1373/clinchem.2004.034611

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Figures & Data
  • Info & Metrics
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • Proteomics of Human Body Fluids. Visith Thongboonkerd, Editor., Totowa, NJ: Humana Press, 2007, 533 pp. (hardcover). ISBN 978-1-59745-432-2.
  • Tietz’s Applied Laboratory Medicine, 2nd ed. Mitchell G. Scott, Ann M. Gronowski, and Charles S. Eby, eds. Hoboken, NJ: Wiley-Interscience, a John Wiley & Sons, Inc. Publication, 2007, 679 pp., $69.95, paperback. ISBN 978-0-471-71457-6.
  • Quick Guide to Coagulation Testing. Marisa B. Marques and George A. Fritsma, Washington, DC: AACC Press, 2006, 62 pp., $15 ($12 AACC members), softcover. ISBN 1-59425-049-9.
Show more Book, Software, and Web Site Reviews

Similar Articles

Options

  • Home
  • About
  • Articles
  • Information for Authors
  • Resources
  • Abstracts
  • Submit
  • Contact
  • RSS

Other Publications

  • The Journal of Applied Laboratory Medicine
Footer logo

© 2019 American Association for Clinical Chemistry

Powered by HighWire