Are Glucokinase Mutations Associated with Low Triglycerides?

Glucokinase mutations in families D_0000_7302 (A; A232D) and Dresden-7 (B; V154fsdelTG).

Black-shaded symbols represent MODY2 patients. Individuals 0206 (A) and I.2 (B) had classic type 2 diabetes but were not MODY2 cases (dark-gray-shaded symbols). Individual 0305 (A) was a mutation carrier for A232D but had no clinical signs of type 2 diabetes (light-gray-shaded symbol). MN in circles/rectangles indicates a heterozygous mutation; NN indicates the wild-type genotype. Genotyped microsatellite markers on chromosome 7 are given on the left. The disease haplotype is shown in black. The sequence with the mutation (exon 7, forward strand) is shown for individual 0305 and the wild-type sequence for individual 0306. The location of the glucokinase gene is indicated by an arrow in the haplotype of individual 0401. CA/AM, current age/age at manifestation; BMI, body mass index; T2D, type 2 diabetes; OHA, oral hypoglycemic agents; CHD, coronary heart disease; GD, gestational diabetes; NE, diabetic neuropathy; FF, fenofibrate therapy.