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OtherNACB Symposium

Standards of laboratory practice: theophylline and caffeine monitoring

Amadeo J. Pesce, Mitchell Rashkin, Uma Kotagal
Published May 1998
Amadeo J. Pesce
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Mitchell Rashkin
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Uma Kotagal
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    Table 1.

    Theophylline and caffeine information.

    DrugHalf-life (range), hTime to steady-stateVD,1 L/kgProtein bindingTherapeutic rangeCritical valueRoute/interval
    TheophyllineAdults (healthy) nonsmokers, 9 (3–12); smokers, 4; adults (liver cirrhosis), 10–56;2–3 days0.5–0.755–65%; <36%, neonates and adults with liver cirrhosis8–20 mg/L, asthma; 6–11 mg/L, neonatal apnea>20 mg/LOral rapid release, 4–6 h; slow release, 12–24 h
    children, 4 (2–10);1–2 days
    infants (4–52 weeks of age), 3–14;1–5 days
    neonates/premature infants, 30;∼6 days
    healthy newborn, 24∼5 days
    CaffeineNeonate, 41–230NA0.6–0.729–43%8–20 mg/L>50 mg/L
    • 1 VD, volume of distribution; and NA, not applicable.

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Vol. 44, Issue 5
May 1998
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Standards of laboratory practice: theophylline and caffeine monitoring
Amadeo J. Pesce, Mitchell Rashkin, Uma Kotagal
Clinical Chemistry May 1998, 44 (5) 1124-1128;
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Standards of laboratory practice: theophylline and caffeine monitoring
Amadeo J. Pesce, Mitchell Rashkin, Uma Kotagal
Clinical Chemistry May 1998, 44 (5) 1124-1128;

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    • Drug Monitoring and Toxicology

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