Article Figures & Data
Tables
Drug Half-life (range), h Time to steady-state VD,1 L/kg Protein binding Therapeutic range Critical value Route/interval Theophylline Adults (healthy) nonsmokers, 9 (3–12); smokers, 4; adults (liver cirrhosis), 10–56; 2–3 days 0.5–0.7 55–65%; <36%, neonates and adults with liver cirrhosis 8–20 mg/L, asthma; 6–11 mg/L, neonatal apnea >20 mg/L Oral rapid release, 4–6 h; slow release, 12–24 h children, 4 (2–10); 1–2 days infants (4–52 weeks of age), 3–14; 1–5 days neonates/premature infants, 30; ∼6 days healthy newborn, 24 ∼5 days Caffeine Neonate, 41–230 NA 0.6–0.7 29–43% 8–20 mg/L >50 mg/L -
1 VD, volume of distribution; and NA, not applicable.
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