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Abstract

A simple method for estimating association constants between monoclonal antibodies and derivatized or native antigens.

W Schramm, T Yang, M E Meyerhoff, L G Bachas
Published July 1990
W Schramm
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T Yang
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M E Meyerhoff
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L G Bachas
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Abstract

We describe a simple method for estimating the association constant between an antibody and an antigen, based on a theoretical treatment of experimental dose-response data. We used this method to calculate the association constants of an anti-progesterone monoclonal antibody for native progesterone and for progesterone 11 alpha-hemisuccinate. These association constants provide a quantitative measure of the bridging-group recognition by the antibody.

  • © 1990 The American Association for Clinical Chemistry
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Vol. 36, Issue 7
July 1990
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A simple method for estimating association constants between monoclonal antibodies and derivatized or native antigens.
W Schramm, T Yang, M E Meyerhoff, L G Bachas
Clinical Chemistry Jul 1990, 36 (7) 1360-1363;
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A simple method for estimating association constants between monoclonal antibodies and derivatized or native antigens.
W Schramm, T Yang, M E Meyerhoff, L G Bachas
Clinical Chemistry Jul 1990, 36 (7) 1360-1363;

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